Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism.

Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism.

Although autism has a clear genetic component, the high genetic heterogeneity of the disorder has been a challenge for the identification of causative genes. We used homozygosity analysis to identify probands from nonconsanguineous families that showed evidence of distant shared ancestry, suggesting...

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Bibliographic Details
Main Authors: Maria H Chahrour, Timothy W Yu, Elaine T Lim, Bulent Ataman, Michael E Coulter, R Sean Hill, Christine R Stevens, Christian R Schubert, ARRA Autism Sequencing Collaboration, Michael E Greenberg, Stacey B Gabriel, Christopher A Walsh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3325173?pdf=render

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http://europepmc.org/articles/PMC3325173?pdf=render

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