A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease
Abstract Background Triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) both bave been related to insulin resistance (IR). The study aimed to investigate the longitudinal relationship between TyG index and NAFLD and to evaluate the ability of TyG, through comparing with...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-11-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0913-3 |
| _version_ | 1818025495241949184 |
|---|---|
| author | Rongjiong Zheng Zhennan Du Mingming Wang Yushan Mao Wenjie Mao |
| author_facet | Rongjiong Zheng Zhennan Du Mingming Wang Yushan Mao Wenjie Mao |
| author_sort | Rongjiong Zheng |
| collection | DOAJ |
| description | Abstract Background Triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) both bave been related to insulin resistance (IR). The study aimed to investigate the longitudinal relationship between TyG index and NAFLD and to evaluate the ability of TyG, through comparing with the predictive value of other indexes, to identify individuals at risk for NAFLD. Methods Four thousand and five hundred thirty nine subjects without NAFLD initially were followed up for 9 years. Cox regression models were used to analyze the risk factors of NAFLD. Results Cox regression analyses indicated the TyG index was independently and positively associated with the risk of incident NAFLD. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for TyG to predict incident NAFLD was 8.52 and the area under the ROC curve (AUC) was 0.76 (95% CI 0.74–0.77), which was larger than that of TG, ALT and FPG. Conclusion This study demonstrated that the elevation of the TyG index might predict increase risk for incident NAFLD and it may be suitable as a diagnostic criterion for NAFLD. |
| first_indexed | 2024-12-10T04:17:01Z |
| format | Article |
| id | doaj.art-2902591aaf704cd28d233abe2a873502 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-10T04:17:01Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-2902591aaf704cd28d233abe2a8735022022-12-22T02:02:33ZengBMCLipids in Health and Disease1476-511X2018-11-011711910.1186/s12944-018-0913-3A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver diseaseRongjiong Zheng0Zhennan Du1Mingming Wang2Yushan Mao3Wenjie Mao4Department of Pulmonology, Ningbo Yinzhou Second HospitalDepartment of Pulmonology, Ningbo Yinzhou Second HospitalDepartment of Pulmonology, Ningbo Yinzhou Second HospitalDepartment of Endocrinology, The Affiliated Hospital of Ningbo University School of MedicineDepartment of Pulmonology, Ningbo Yinzhou Second HospitalAbstract Background Triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) both bave been related to insulin resistance (IR). The study aimed to investigate the longitudinal relationship between TyG index and NAFLD and to evaluate the ability of TyG, through comparing with the predictive value of other indexes, to identify individuals at risk for NAFLD. Methods Four thousand and five hundred thirty nine subjects without NAFLD initially were followed up for 9 years. Cox regression models were used to analyze the risk factors of NAFLD. Results Cox regression analyses indicated the TyG index was independently and positively associated with the risk of incident NAFLD. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for TyG to predict incident NAFLD was 8.52 and the area under the ROC curve (AUC) was 0.76 (95% CI 0.74–0.77), which was larger than that of TG, ALT and FPG. Conclusion This study demonstrated that the elevation of the TyG index might predict increase risk for incident NAFLD and it may be suitable as a diagnostic criterion for NAFLD.http://link.springer.com/article/10.1186/s12944-018-0913-3Nonalcoholic fatty liver diseaseThe triglyceride and glucose indexInsulin resistanceEpidemiology |
| spellingShingle | Rongjiong Zheng Zhennan Du Mingming Wang Yushan Mao Wenjie Mao A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease Lipids in Health and Disease Nonalcoholic fatty liver disease The triglyceride and glucose index Insulin resistance Epidemiology |
| title | A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| title_full | A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| title_fullStr | A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| title_full_unstemmed | A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| title_short | A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| title_sort | longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease |
| topic | Nonalcoholic fatty liver disease The triglyceride and glucose index Insulin resistance Epidemiology |
| url | http://link.springer.com/article/10.1186/s12944-018-0913-3 |
| work_keys_str_mv | AT rongjiongzheng alongitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT zhennandu alongitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT mingmingwang alongitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT yushanmao alongitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT wenjiemao alongitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT rongjiongzheng longitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT zhennandu longitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT mingmingwang longitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT yushanmao longitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease AT wenjiemao longitudinalepidemiologicalstudyonthetriglycerideandglucoseindexandtheincidentnonalcoholicfattyliverdisease |