Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal

Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal

Background Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD). The disturbance of hemodynamics can induce valvular calcification, but the mechanism has not been fully identified. Methods We constructed a finite elemen...

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Bibliographic Details
Main Authors: Guangzhou Li, Na Shen, Huifang Deng, Yixuan Wang, Gangcheng Kong, Jiawei Shi, Nianguo Dong, Cheng Deng
Format: Article
Language:English
Published: PeerJ Inc. 2023-03-01
Series:PeerJ
Subjects:
Bicuspid aortic valve
Finite element analysis
Valvular calcification
Mechanical stimuli
Notch1 signaling pathway
Online Access:https://peerj.com/articles/14950.pdf

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