The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study
Objective: This study investigates the effects of a behavioral lifestyle intervention on inflammatory cytokines and frailty in older adults (≥ 65 years) with type 2 diabetes (T2D). Method: We conducted a single-arm, 6-month intervention supplemented with diet and activity self-monitoring technology....
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| 格式: | 文件 |
| 语言: | English |
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SAGE Publishing
2024-04-01
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| 丛编: | Inquiry: The Journal of Health Care Organization, Provision, and Financing |
| 在线阅读: | https://doi.org/10.1177/00469580241248126 |
| _version_ | 1827277469848174592 |
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| author | Rozmin Jiwani PhD, RN Monica Serra PhD Sara Espinoza MD Andrea Berndt PhD Darpan Patel PhD |
| author_facet | Rozmin Jiwani PhD, RN Monica Serra PhD Sara Espinoza MD Andrea Berndt PhD Darpan Patel PhD |
| author_sort | Rozmin Jiwani PhD, RN |
| collection | DOAJ |
| description | Objective: This study investigates the effects of a behavioral lifestyle intervention on inflammatory cytokines and frailty in older adults (≥ 65 years) with type 2 diabetes (T2D). Method: We conducted a single-arm, 6-month intervention supplemented with diet and activity self-monitoring technology. We assessed frailty using Fried criteria and quantified inflammatory cytokines (interleukin [IL]-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating-factor [GM-CSF], interferon [IFN-γ], tumor necrosis factor [TNF-α]) using a multiplex assay. We used paired t-tests with significance at P < .05. We calculated the Spearman correlation and evaluated the relationship between frailty, BMI, and inflammatory cytokines. Results: Eighteen participants completed the study (mean ± SD: 71.5 ± 5.3 years; BMI: 34 ± 6 kg/m 2 ). At baseline, we had 4 frail, 13 pre-frail, and 1 non-frail participant. At 6 months, we observed the therapeutic effects of the intervention on frailty score, BMI, IL-2, IFN-y, and GM-CSF. Discussion: The study highlights the importance of behavioral lifestyle intervention in improving inflammatory cytokines and frailty in older adults. |
| first_indexed | 2024-04-24T07:22:51Z |
| format | Article |
| id | doaj.art-290490617cd74d5eb24e234592be416b |
| institution | Directory Open Access Journal |
| issn | 0046-9580 1945-7243 |
| language | English |
| last_indexed | 2024-04-24T07:22:51Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Inquiry: The Journal of Health Care Organization, Provision, and Financing |
| spelling | doaj.art-290490617cd74d5eb24e234592be416b2024-04-20T18:03:20ZengSAGE PublishingInquiry: The Journal of Health Care Organization, Provision, and Financing0046-95801945-72432024-04-016110.1177/00469580241248126The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility StudyRozmin Jiwani PhD, RN0Monica Serra PhD1Sara Espinoza MD2Andrea Berndt PhD3Darpan Patel PhD4South Texas Veterans Health Care System, San Antonio, TX, USASouth Texas Veterans Health Care System, San Antonio, TX, USACedars-Sinai Medical CenterUniversity of Texas Health Science Center at San Antonio, TX, USAThe University of Texas Medical Branch, Galveston, TX, USAObjective: This study investigates the effects of a behavioral lifestyle intervention on inflammatory cytokines and frailty in older adults (≥ 65 years) with type 2 diabetes (T2D). Method: We conducted a single-arm, 6-month intervention supplemented with diet and activity self-monitoring technology. We assessed frailty using Fried criteria and quantified inflammatory cytokines (interleukin [IL]-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating-factor [GM-CSF], interferon [IFN-γ], tumor necrosis factor [TNF-α]) using a multiplex assay. We used paired t-tests with significance at P < .05. We calculated the Spearman correlation and evaluated the relationship between frailty, BMI, and inflammatory cytokines. Results: Eighteen participants completed the study (mean ± SD: 71.5 ± 5.3 years; BMI: 34 ± 6 kg/m 2 ). At baseline, we had 4 frail, 13 pre-frail, and 1 non-frail participant. At 6 months, we observed the therapeutic effects of the intervention on frailty score, BMI, IL-2, IFN-y, and GM-CSF. Discussion: The study highlights the importance of behavioral lifestyle intervention in improving inflammatory cytokines and frailty in older adults.https://doi.org/10.1177/00469580241248126 |
| spellingShingle | Rozmin Jiwani PhD, RN Monica Serra PhD Sara Espinoza MD Andrea Berndt PhD Darpan Patel PhD The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study Inquiry: The Journal of Health Care Organization, Provision, and Financing |
| title | The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study |
| title_full | The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study |
| title_fullStr | The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study |
| title_full_unstemmed | The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study |
| title_short | The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study |
| title_sort | impact of behavioral lifestyle intervention on inflammatory cytokines in older adults living with type 2 diabetes a feasibility study |
| url | https://doi.org/10.1177/00469580241248126 |
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