The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial
Introduction: Rapid bone loss after menopause is partly due to the formation of free radicals; the phenolic compounds of some plants eliminate these free radicals and most likely suppress bone destruction. This study was performed with aim to compare the effect of vitex and salvia officinalis extrac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2021-11-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_19389_63c5872546de5412c60125dd0098afb4.pdf |
| _version_ | 1811328959164448768 |
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| author | Afsaneh Zeidabadi Mohammad Hosein Dabbaghmanesh Mohammad Reza Sasani Masoumeh Emamghoreishi Marziyeh Akbarzade |
| author_facet | Afsaneh Zeidabadi Mohammad Hosein Dabbaghmanesh Mohammad Reza Sasani Masoumeh Emamghoreishi Marziyeh Akbarzade |
| author_sort | Afsaneh Zeidabadi |
| collection | DOAJ |
| description | Introduction: Rapid bone loss after menopause is partly due to the formation of free radicals; the phenolic compounds of some plants eliminate these free radicals and most likely suppress bone destruction. This study was performed with aim to compare the effect of vitex and salvia officinalis extract on some osteogenic factors in postmenopausal women.
Methods: This triple-blind randomized clinical trial study was performed in 2015 on 99 postmenopausal women referred to the bone mass density center. The subjects were randomly divided into three groups of Vitex tablet, Salvia Officinalis extract and placebo; the intervention was performed for 3 months. Tests for osteogenic factors (alkaline phosphatase, osteocalcin, telopeptide-c (CTx)) were performed before and after the intervention. Chi-square, analysis of variance, paired t-test and LSD post hoc tests were used. P<0.05 was considered statistically significant.
Results: Mean alkaline phosphatase, osteocalcin and telopeptide-c decreased after the intervention compared to before the intervention in the vitex and salvia officinalis groups (p<0.001). Based on the results of LSD post hoc test, the difference between the mean scores of alkaline phosphatase (p <0.05), osteocalcin and telopeptide-c was significantly different between the vitex and salvia officinalis groups with the control group after the intervention (p <0.05), but the difference of mean score of telopeptide-c was not statistically significant between the vitex and salvia officinalis groups after the intervention (p = 0.118).
Conclusion: Vitex and Salvia Officinalis extract after the intervention were effective in reducing some estrogenic factors such as alkaline phosphatase, osteocalcin and telopeptide c after the intervention. |
| first_indexed | 2024-04-13T15:34:04Z |
| format | Article |
| id | doaj.art-29054b60003d4d049df7be5868a26255 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-13T15:34:04Z |
| publishDate | 2021-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-29054b60003d4d049df7be5868a262552022-12-22T02:41:18ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-11-012410486010.22038/ijogi.2021.1938919389The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trialAfsaneh Zeidabadi0Mohammad Hosein Dabbaghmanesh1Mohammad Reza Sasani2Masoumeh Emamghoreishi3Marziyeh Akbarzade4Instructor, Department of Midwifery, Community Mental Health Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.Professor, Department of Endocrinology, Endocrine and Metabolism Research Center, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Assistant professor, Department of Radiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Professor, Department of Pharmacology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Assistant professor, Department of Midwifery, Maternal-Fetal Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.Introduction: Rapid bone loss after menopause is partly due to the formation of free radicals; the phenolic compounds of some plants eliminate these free radicals and most likely suppress bone destruction. This study was performed with aim to compare the effect of vitex and salvia officinalis extract on some osteogenic factors in postmenopausal women. Methods: This triple-blind randomized clinical trial study was performed in 2015 on 99 postmenopausal women referred to the bone mass density center. The subjects were randomly divided into three groups of Vitex tablet, Salvia Officinalis extract and placebo; the intervention was performed for 3 months. Tests for osteogenic factors (alkaline phosphatase, osteocalcin, telopeptide-c (CTx)) were performed before and after the intervention. Chi-square, analysis of variance, paired t-test and LSD post hoc tests were used. P<0.05 was considered statistically significant. Results: Mean alkaline phosphatase, osteocalcin and telopeptide-c decreased after the intervention compared to before the intervention in the vitex and salvia officinalis groups (p<0.001). Based on the results of LSD post hoc test, the difference between the mean scores of alkaline phosphatase (p <0.05), osteocalcin and telopeptide-c was significantly different between the vitex and salvia officinalis groups with the control group after the intervention (p <0.05), but the difference of mean score of telopeptide-c was not statistically significant between the vitex and salvia officinalis groups after the intervention (p = 0.118). Conclusion: Vitex and Salvia Officinalis extract after the intervention were effective in reducing some estrogenic factors such as alkaline phosphatase, osteocalcin and telopeptide c after the intervention.https://ijogi.mums.ac.ir/article_19389_63c5872546de5412c60125dd0098afb4.pdfbone density measurement centerosteogenic factorspostmenopausalsalvia officinalis xtractvitex |
| spellingShingle | Afsaneh Zeidabadi Mohammad Hosein Dabbaghmanesh Mohammad Reza Sasani Masoumeh Emamghoreishi Marziyeh Akbarzade The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān bone density measurement center osteogenic factors postmenopausal salvia officinalis xtract vitex |
| title | The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial |
| title_full | The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial |
| title_fullStr | The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial |
| title_full_unstemmed | The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial |
| title_short | The Effect of Vitex and Salvia Officinalis Extract on Some Osteogenic Factors in Postmenopausal Women: A triple-blind randomized clinical trial |
| title_sort | effect of vitex and salvia officinalis extract on some osteogenic factors in postmenopausal women a triple blind randomized clinical trial |
| topic | bone density measurement center osteogenic factors postmenopausal salvia officinalis xtract vitex |
| url | https://ijogi.mums.ac.ir/article_19389_63c5872546de5412c60125dd0098afb4.pdf |
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