A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1
?2 microglobulin (?2M) fibril has been recognized as the major factor of dialysis-related amyloidosis. Elevated serum levels are thought to be the basis for tissue deposition. In order to evaluate the effect of cellulosis membrane (FB 110) and treatment duration on S?2M levels, we determined serum l...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2000-07-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5544.pdf&manuscript_id=5544 |
| _version_ | 1818268665333678080 |
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| author | Mirahmadian M Rezaeei A Nikbeen B |
| author_facet | Mirahmadian M Rezaeei A Nikbeen B |
| author_sort | Mirahmadian M |
| collection | DOAJ |
| description | ?2 microglobulin (?2M) fibril has been recognized as the major factor of dialysis-related amyloidosis. Elevated serum levels are thought to be the basis for tissue deposition. In order to evaluate the effect of cellulosis membrane (FB 110) and treatment duration on S?2M levels, we determined serum levels in 23 hemodialyzed patients with end-stage renal failure. S?2M levels were markedly elevated in all patients with a mean of 74.71 (SD=21.2 mg/l, range: 46 mg/l after 2 years hemodialysis-123.8 mg/l after 10 years treatment) that statistically is higher than healthy subjects (P<0.0001). Serum ?2M in 19 healthy subjects was 2.36 (SD=0.4 mg/l, rang: 1.58-3.3 mg/l). Although in hemodialysis group, no significant correlation was found between S?2M and age or sex but increased serum levels of ?2M had significant correlation with duration of hemodialysis treatment (r=0.53, P<0.01). Since the dialysis membrane has a very effective role in clearance of S?2M, we suggest that the particular effort should be made towards improvement of dialysis membranes. |
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| format | Article |
| id | doaj.art-2907c2630f28462599c0e6b983eba996 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-12T20:42:06Z |
| publishDate | 2000-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-2907c2630f28462599c0e6b983eba9962022-12-22T00:12:41ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222000-07-015826670A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1Mirahmadian MRezaeei ANikbeen B?2 microglobulin (?2M) fibril has been recognized as the major factor of dialysis-related amyloidosis. Elevated serum levels are thought to be the basis for tissue deposition. In order to evaluate the effect of cellulosis membrane (FB 110) and treatment duration on S?2M levels, we determined serum levels in 23 hemodialyzed patients with end-stage renal failure. S?2M levels were markedly elevated in all patients with a mean of 74.71 (SD=21.2 mg/l, range: 46 mg/l after 2 years hemodialysis-123.8 mg/l after 10 years treatment) that statistically is higher than healthy subjects (P<0.0001). Serum ?2M in 19 healthy subjects was 2.36 (SD=0.4 mg/l, rang: 1.58-3.3 mg/l). Although in hemodialysis group, no significant correlation was found between S?2M and age or sex but increased serum levels of ?2M had significant correlation with duration of hemodialysis treatment (r=0.53, P<0.01). Since the dialysis membrane has a very effective role in clearance of S?2M, we suggest that the particular effort should be made towards improvement of dialysis membranes.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5544.pdf&manuscript_id=55442-MicroglobulinDialysis membranesCellulosis membranes |
| spellingShingle | Mirahmadian M Rezaeei A Nikbeen B A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 Tehran University Medical Journal 2-Microglobulin Dialysis membranes Cellulosis membranes |
| title | A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 |
| title_full | A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 |
| title_fullStr | A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 |
| title_full_unstemmed | A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 |
| title_short | A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1 |
| title_sort | study of serum 2 microglobulin s 2m in hemodialysis patients with cellulosis membrane1 |
| topic | 2-Microglobulin Dialysis membranes Cellulosis membranes |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5544.pdf&manuscript_id=5544 |
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