Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application
The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds thr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/10/2392 |
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| author | Maria Natalia Calienni Luis Manuel Martínez Maria Cecilia Izquierdo Silvia del Valle Alonso Jorge Montanari |
| author_facet | Maria Natalia Calienni Luis Manuel Martínez Maria Cecilia Izquierdo Silvia del Valle Alonso Jorge Montanari |
| author_sort | Maria Natalia Calienni |
| collection | DOAJ |
| description | The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds through the skin, and are applicable in pharmaceuticals and cosmetics. Formulations underwent flow analysis and were fitted to the Herschel–Bulkley model due to their prevalent non-Newtonian behavior in most cases. Linear viscoelastic regions (LVR) were identified, and G′ and G″ moduli were determined via frequency sweep steps, considering the impact of temperature and aging. The formulations exhibited non-Newtonian behavior with pseudoplastic traits in most cases, with UDL incorporation inducing rheological changes. LVR and frequency sweep tests indicated predominantly elastic solid behavior, with G′ higher than G″, at different temperatures and post-production times. Tan δ values also illustrated a predominant solid-like behavior over liquid. This study provides pivotal insights into the rheological and viscoelastic features of topical formulations, emphasizing the crucial role of meticulous vehicle and formulation selection when incorporating UDL or analogous liposomal drug delivery systems. |
| first_indexed | 2024-03-10T20:58:26Z |
| format | Article |
| id | doaj.art-290944407329478e9a9d9ebdaa1cbb1c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:58:26Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-290944407329478e9a9d9ebdaa1cbb1c2023-11-19T17:43:52ZengMDPI AGPharmaceutics1999-49232023-09-011510239210.3390/pharmaceutics15102392Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical ApplicationMaria Natalia Calienni0Luis Manuel Martínez1Maria Cecilia Izquierdo2Silvia del Valle Alonso3Jorge Montanari4Laboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, ArgentinaLaboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, ArgentinaLaboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, ArgentinaLaboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, ArgentinaLaboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, ArgentinaThe rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds through the skin, and are applicable in pharmaceuticals and cosmetics. Formulations underwent flow analysis and were fitted to the Herschel–Bulkley model due to their prevalent non-Newtonian behavior in most cases. Linear viscoelastic regions (LVR) were identified, and G′ and G″ moduli were determined via frequency sweep steps, considering the impact of temperature and aging. The formulations exhibited non-Newtonian behavior with pseudoplastic traits in most cases, with UDL incorporation inducing rheological changes. LVR and frequency sweep tests indicated predominantly elastic solid behavior, with G′ higher than G″, at different temperatures and post-production times. Tan δ values also illustrated a predominant solid-like behavior over liquid. This study provides pivotal insights into the rheological and viscoelastic features of topical formulations, emphasizing the crucial role of meticulous vehicle and formulation selection when incorporating UDL or analogous liposomal drug delivery systems.https://www.mdpi.com/1999-4923/15/10/2392skintopical productsliposomescreamgelthermal water |
| spellingShingle | Maria Natalia Calienni Luis Manuel Martínez Maria Cecilia Izquierdo Silvia del Valle Alonso Jorge Montanari Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application Pharmaceutics skin topical products liposomes cream gel thermal water |
| title | Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application |
| title_full | Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application |
| title_fullStr | Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application |
| title_full_unstemmed | Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application |
| title_short | Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application |
| title_sort | rheological and viscoelastic analysis of hybrid formulations for topical application |
| topic | skin topical products liposomes cream gel thermal water |
| url | https://www.mdpi.com/1999-4923/15/10/2392 |
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