An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1
Interferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction. In this article, I review the relevant previous works and propose a cell cycle-based, tumor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1173467/full |
| _version_ | 1797838559694028800 |
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| author | Albert Qin |
| author_facet | Albert Qin |
| author_sort | Albert Qin |
| collection | DOAJ |
| description | Interferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction. In this article, I review the relevant previous works and propose a cell cycle-based, tumor suppressor protein-mediated mechanism of anti-cancer surveillance. IFN-β induces a tumor cell cycle alteration that leads to S phase accumulation, senescence entry, and a loss of tumorigenicity in solid tumor cells. IFN-β does not show a significant cell cycle effect in their normal counterparts. Retinoblastoma protein RB1, another tumor suppressor protein, tightly controls the cell cycle and differentiation of normal cells, preventing them from being significantly impacted by the IFN-β effect. The interplay between IFN-β and RB1 acts as a mechanism of cell cycle-based, tumor suppressor protein-mediated anti-cancer surveillance that can selectively suppress solid tumor or proliferating transformed cells from the loss of control leading to cancer. This mechanism has important implications for the treatment of solid tumors. |
| first_indexed | 2024-04-09T15:43:54Z |
| format | Article |
| id | doaj.art-2909c3df95fb4df2815ffa902ad9c160 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T15:43:54Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2909c3df95fb4df2815ffa902ad9c1602023-04-27T05:27:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11734671173467An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1Albert QinInterferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction. In this article, I review the relevant previous works and propose a cell cycle-based, tumor suppressor protein-mediated mechanism of anti-cancer surveillance. IFN-β induces a tumor cell cycle alteration that leads to S phase accumulation, senescence entry, and a loss of tumorigenicity in solid tumor cells. IFN-β does not show a significant cell cycle effect in their normal counterparts. Retinoblastoma protein RB1, another tumor suppressor protein, tightly controls the cell cycle and differentiation of normal cells, preventing them from being significantly impacted by the IFN-β effect. The interplay between IFN-β and RB1 acts as a mechanism of cell cycle-based, tumor suppressor protein-mediated anti-cancer surveillance that can selectively suppress solid tumor or proliferating transformed cells from the loss of control leading to cancer. This mechanism has important implications for the treatment of solid tumors.https://www.frontiersin.org/articles/10.3389/fonc.2023.1173467/fulltumorigenicitycell cycle-based anti-cancer surveillancetumor suppressor protein-mediated mechanisminterferon-beta (IFN-β)retinoblastoma protein RB1 |
| spellingShingle | Albert Qin An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 Frontiers in Oncology tumorigenicity cell cycle-based anti-cancer surveillance tumor suppressor protein-mediated mechanism interferon-beta (IFN-β) retinoblastoma protein RB1 |
| title | An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 |
| title_full | An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 |
| title_fullStr | An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 |
| title_full_unstemmed | An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 |
| title_short | An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1 |
| title_sort | anti cancer surveillance by the interplay between interferon beta and retinoblastoma protein rb1 |
| topic | tumorigenicity cell cycle-based anti-cancer surveillance tumor suppressor protein-mediated mechanism interferon-beta (IFN-β) retinoblastoma protein RB1 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1173467/full |
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