MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study

Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance (MDR), an obstacle to cancer therapy. Our recent study uncovered that the MET inhibitor, tepotinib, is a potent reversal agent for ABCB1-mediated MDR. In the present study, we reported for...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Zhuo-Xun Wu, Qiu-Xu Teng, Yuqi Yang, Nikita Acharekar, Jing-Quan Wang, Min He, Sabesan Yoganathan, Jun Lin, Jian Wang, Zhe-Sheng Chen
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2022-05-01
Sraith:Acta Pharmaceutica Sinica B
Ábhair:
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211383521004901