A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes
Background and Objectives: Undescended testes (UDT) or cryptorchidism is a common congenital disability characterised by the absence of at least one testicle from the scrotum. The primary aim of surgical correction is to preserve fertility potential and prevent complications including trauma, malign...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | African Journal of Paediatric Surgery |
| Subjects: | |
| Online Access: | http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2022;volume=19;issue=4;spage=233;epage=237;aulast=Raman |
| _version_ | 1798037570383249408 |
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| author | V Shankar Raman Sanath Khanna Vishesh Verma |
| author_facet | V Shankar Raman Sanath Khanna Vishesh Verma |
| author_sort | V Shankar Raman |
| collection | DOAJ |
| description | Background and Objectives: Undescended testes (UDT) or cryptorchidism is a common congenital disability characterised by the absence of at least one testicle from the scrotum. The primary aim of surgical correction is to preserve fertility potential and prevent complications including trauma, malignancy, hernia and torsion. Often, children, especially in developing countries, present late with UDT. The effect of surgical correction in the recovery of Sertoli cell function in children aged more than 2 years is not apparent. The present study was conducted to study the change in inhibin-B level as a marker of Sertoli cell function in surgically corrected UDT in a heterogeneous population. Materials and Methods: A prospective observational study conducted over a 3-year period at a tertiary care paediatric surgery centre recruited 76 children with UDT undergoing surgical correction. Inhibin-B as a marker for Sertoli cell function was studied preoperatively and postoperatively. Continuous variables were summarised by calculating mean, standard deviation, median and interquartile range (IQR). Quantile versus quantile plotting was done to assess the distribution of the data. Data were analysed in two groups, with participants aged <2 years (Group A) and more than 2 years (Group B). Wilcoxon signed-rank test was used to compare the pre-operative and post-operative value. Results: In Group A (n = 39), the median (IQR) of pre-operative inhibin-B was 181 pg/ml (148–254) and post-operative inhibin-B was 230 pg/ml (176–296). In Group B, the median (IQR) of pre-operative inhibin was 70 pg/ml (44–104) and post-operative inhibin was 102 pg/ml (46–176). There was a significant increase in post-operative inhibin when compared to the pre-operative inhibin (P = 0.015 and 0.012, respectively, in Group A and B). Luteinizing hormone (LH) showed a significant decrease (P = 0.002) in Group A following surgery but bordering on significance in Group B (P = 0.43). On the other hand, follicle-stimulating hormone showed a significant decrease (P < 0.01) in Group B following surgery but not in Group A (P = 0.87). Conclusion: The mean post-operative inhibin-B levels were increased significantly as compared to the pre-operative levels indicating either a successful orchiopexy/adequate germ cell number or both. The benefit of orchiopexy may extend even to children presenting late for evaluation. |
| first_indexed | 2024-04-11T21:28:20Z |
| format | Article |
| id | doaj.art-290b612e3825462b9273b15eb553a650 |
| institution | Directory Open Access Journal |
| issn | 0189-6725 |
| language | English |
| last_indexed | 2024-04-11T21:28:20Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | African Journal of Paediatric Surgery |
| spelling | doaj.art-290b612e3825462b9273b15eb553a6502022-12-22T04:02:18ZengWolters Kluwer Medknow PublicationsAfrican Journal of Paediatric Surgery0189-67252022-01-0119423323710.4103/ajps.ajps_96_21A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testesV Shankar RamanSanath KhannaVishesh VermaBackground and Objectives: Undescended testes (UDT) or cryptorchidism is a common congenital disability characterised by the absence of at least one testicle from the scrotum. The primary aim of surgical correction is to preserve fertility potential and prevent complications including trauma, malignancy, hernia and torsion. Often, children, especially in developing countries, present late with UDT. The effect of surgical correction in the recovery of Sertoli cell function in children aged more than 2 years is not apparent. The present study was conducted to study the change in inhibin-B level as a marker of Sertoli cell function in surgically corrected UDT in a heterogeneous population. Materials and Methods: A prospective observational study conducted over a 3-year period at a tertiary care paediatric surgery centre recruited 76 children with UDT undergoing surgical correction. Inhibin-B as a marker for Sertoli cell function was studied preoperatively and postoperatively. Continuous variables were summarised by calculating mean, standard deviation, median and interquartile range (IQR). Quantile versus quantile plotting was done to assess the distribution of the data. Data were analysed in two groups, with participants aged <2 years (Group A) and more than 2 years (Group B). Wilcoxon signed-rank test was used to compare the pre-operative and post-operative value. Results: In Group A (n = 39), the median (IQR) of pre-operative inhibin-B was 181 pg/ml (148–254) and post-operative inhibin-B was 230 pg/ml (176–296). In Group B, the median (IQR) of pre-operative inhibin was 70 pg/ml (44–104) and post-operative inhibin was 102 pg/ml (46–176). There was a significant increase in post-operative inhibin when compared to the pre-operative inhibin (P = 0.015 and 0.012, respectively, in Group A and B). Luteinizing hormone (LH) showed a significant decrease (P = 0.002) in Group A following surgery but bordering on significance in Group B (P = 0.43). On the other hand, follicle-stimulating hormone showed a significant decrease (P < 0.01) in Group B following surgery but not in Group A (P = 0.87). Conclusion: The mean post-operative inhibin-B levels were increased significantly as compared to the pre-operative levels indicating either a successful orchiopexy/adequate germ cell number or both. The benefit of orchiopexy may extend even to children presenting late for evaluation.http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2022;volume=19;issue=4;spage=233;epage=237;aulast=Ramaninhibin-borchiopexyundescended testes |
| spellingShingle | V Shankar Raman Sanath Khanna Vishesh Verma A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes African Journal of Paediatric Surgery inhibin-b orchiopexy undescended testes |
| title | A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| title_full | A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| title_fullStr | A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| title_full_unstemmed | A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| title_short | A prospective observational study to evaluate the change in inhibin-B as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| title_sort | prospective observational study to evaluate the change in inhibin b as a marker of sertoli cell function in children subjected to surgical correction for undescended testes |
| topic | inhibin-b orchiopexy undescended testes |
| url | http://www.afrjpaedsurg.org/article.asp?issn=0189-6725;year=2022;volume=19;issue=4;spage=233;epage=237;aulast=Raman |
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