Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs
IntroductionThe purpose of this study was to explore the effects of tea polyphenols on growth performance, cytokine content, intestinal antioxidant status and intestinal barrier function of lambs, in order to provide reference for intestinal health of ruminants.MethodsThirty weaned lambs (average in...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1361507/full |
| _version_ | 1797305281461354496 |
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| author | Yuewen Xu Yuewen Xu Fuquan Yin Fuquan Yin Jialin Wang Jialin Wang Pengxin Wu Pengxin Wu Xiaoyuan Qiu Xiaoyuan Qiu Xiaolin He Yimei Xiao Shangquan Gan Shangquan Gan |
| author_facet | Yuewen Xu Yuewen Xu Fuquan Yin Fuquan Yin Jialin Wang Jialin Wang Pengxin Wu Pengxin Wu Xiaoyuan Qiu Xiaoyuan Qiu Xiaolin He Yimei Xiao Shangquan Gan Shangquan Gan |
| author_sort | Yuewen Xu |
| collection | DOAJ |
| description | IntroductionThe purpose of this study was to explore the effects of tea polyphenols on growth performance, cytokine content, intestinal antioxidant status and intestinal barrier function of lambs, in order to provide reference for intestinal health of ruminants.MethodsThirty weaned lambs (average initial weight 9.32 ± 1.72 kg) were randomly divided into five groups with six lambs in each group. The control group did not add anything but the basic diet mainly composed of Pennisetum and Corn, and the other four groups added 2, 4, 6 g/kg tea polyphenols and 50 mg/kg chlortetracycline to the basic diet, respectively. The experiment lasted for 42 days.ResultsDietary tea polyphenols improved the growth and stress response and reduced intestinal permeability of lambs (p > 0.05), while CTC did not affect the final lamb weight (p > 0.05). Both tea phenols and CTC significantly reduced inflammatory factors and enhanced the immune system (p > 0.05). Dietary tea polyphenols increased villus height, villus height/crypt depth, secretory immunoglobulin A (p > 0.05), and antioxidant enzymes, while decreasing MDA and apoptosis in the intestine (p > 0.05). However, compared with other groups, the content of T-AOC in jejunum did not change significantly (p > 0.05). Tea polyphenols also increased claudin-1 levels in the duodenum, jejunum, and ileum more than CTC (p > 0.05). CTC had a limited effect on the mRNA expression of Occludin and ZO-1, while tea polyphenols increased these in both the duodenum and ileum (p > 0.05).ConclusionThis study demonstrated that tea polyphenols can effectively improve the intestinal barrier of weaned lambs, and that they have anti-inflammatory and antioxidant effects similar to those of antibiotics. Thus, tea polyphenols could be used to replace antibiotics in ensuring safety of livestock products and in achieving the sustainable development of modern animal husbandry. |
| first_indexed | 2024-03-08T00:23:37Z |
| format | Article |
| id | doaj.art-290e7ffb32f4457196797d3fa76aa27b |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-08T00:23:37Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-290e7ffb32f4457196797d3fa76aa27b2024-02-16T04:25:45ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-02-011110.3389/fvets.2024.13615071361507Effect of tea polyphenols on intestinal barrier and immune function in weaned lambsYuewen Xu0Yuewen Xu1Fuquan Yin2Fuquan Yin3Jialin Wang4Jialin Wang5Pengxin Wu6Pengxin Wu7Xiaoyuan Qiu8Xiaoyuan Qiu9Xiaolin He10Yimei Xiao11Shangquan Gan12Shangquan Gan13College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaCollege of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang, ChinaThe Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Department of Animal Science, Guangdong Ocean University, Zhanjiang, ChinaIntroductionThe purpose of this study was to explore the effects of tea polyphenols on growth performance, cytokine content, intestinal antioxidant status and intestinal barrier function of lambs, in order to provide reference for intestinal health of ruminants.MethodsThirty weaned lambs (average initial weight 9.32 ± 1.72 kg) were randomly divided into five groups with six lambs in each group. The control group did not add anything but the basic diet mainly composed of Pennisetum and Corn, and the other four groups added 2, 4, 6 g/kg tea polyphenols and 50 mg/kg chlortetracycline to the basic diet, respectively. The experiment lasted for 42 days.ResultsDietary tea polyphenols improved the growth and stress response and reduced intestinal permeability of lambs (p > 0.05), while CTC did not affect the final lamb weight (p > 0.05). Both tea phenols and CTC significantly reduced inflammatory factors and enhanced the immune system (p > 0.05). Dietary tea polyphenols increased villus height, villus height/crypt depth, secretory immunoglobulin A (p > 0.05), and antioxidant enzymes, while decreasing MDA and apoptosis in the intestine (p > 0.05). However, compared with other groups, the content of T-AOC in jejunum did not change significantly (p > 0.05). Tea polyphenols also increased claudin-1 levels in the duodenum, jejunum, and ileum more than CTC (p > 0.05). CTC had a limited effect on the mRNA expression of Occludin and ZO-1, while tea polyphenols increased these in both the duodenum and ileum (p > 0.05).ConclusionThis study demonstrated that tea polyphenols can effectively improve the intestinal barrier of weaned lambs, and that they have anti-inflammatory and antioxidant effects similar to those of antibiotics. Thus, tea polyphenols could be used to replace antibiotics in ensuring safety of livestock products and in achieving the sustainable development of modern animal husbandry.https://www.frontiersin.org/articles/10.3389/fvets.2024.1361507/fulltea polyphenolweaned lambintestinal barrierantioxidant capacityimmune function |
| spellingShingle | Yuewen Xu Yuewen Xu Fuquan Yin Fuquan Yin Jialin Wang Jialin Wang Pengxin Wu Pengxin Wu Xiaoyuan Qiu Xiaoyuan Qiu Xiaolin He Yimei Xiao Shangquan Gan Shangquan Gan Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs Frontiers in Veterinary Science tea polyphenol weaned lamb intestinal barrier antioxidant capacity immune function |
| title | Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| title_full | Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| title_fullStr | Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| title_full_unstemmed | Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| title_short | Effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| title_sort | effect of tea polyphenols on intestinal barrier and immune function in weaned lambs |
| topic | tea polyphenol weaned lamb intestinal barrier antioxidant capacity immune function |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1361507/full |
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