A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells

A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells

Aberrant glycosylation plays a crucial role in tumour progression and invasiveness. Tumour-associated carbohydrate antigens (TACAs) represent a valuable set of targets for immunotherapeutic approaches. The poor immunogenicity of glycan structures, however, requires a more effective and well-directed...

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Bibliographic Details
Main Authors: Jana Tomisch, Vincent Busse, Francesca Rosato, Olga N. Makshakova, Pavel Salavei, Anna-Sophia Kittel, Emilie Gillon, Levin Lataster, Anne Imberty, Ana Valeria Meléndez, Winfried Römer
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
bispecific T cell engager
lectins
Shiga toxin B-subunit
cancer immunotherapy
tumour-associated carbohydrate antigens
globotriaosylceramide
Online Access:https://www.mdpi.com/2073-4409/12/14/1896

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