<title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles
A survey was conducted in the hemodialysis population of the state of Tocantins, Brazil, aiming to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, to analyze associated risk factors, and also to investigate these viruses genotypes distribution. During January...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2003-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500003 |
| _version_ | 1797756824329388032 |
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| author | Karla P Souza Jônio A Luz Sheila A Teles Megmar AS Carneiro Luciana A Oliveira Adriane S Gomes Márcia A Dias Selma A Gomes Clara FT Yoshida Regina MB Martins |
| author_facet | Karla P Souza Jônio A Luz Sheila A Teles Megmar AS Carneiro Luciana A Oliveira Adriane S Gomes Márcia A Dias Selma A Gomes Clara FT Yoshida Regina MB Martins |
| author_sort | Karla P Souza |
| collection | DOAJ |
| description | A survey was conducted in the hemodialysis population of the state of Tocantins, Brazil, aiming to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, to analyze associated risk factors, and also to investigate these viruses genotypes distribution. During January and March 2001, all patients (n = 100) were interviewed at the unique dialysis unit in Tocantins. Blood samples were collected and serum samples were screened for HBV serological markers. Hepatitis B surface antigen positive samples were tested for HBV DNA. All samples were also tested for anti-HCV antibodies and HCV RNA. An overall prevalence of 45% was found for HBV infection (4% were HBsAg/anti-HBc positive, 2% were anti-HBc only and 39% had anti-HBc/anti-HBs markers). Concerning HCV infection, anti-HCV and HCV RNA were detected in 13% and 14% of the subjects, respectively. Three patients were HCV RNA positive and anti-HCV negative, resulting in an overall HCV prevalence of 16%. Univariate analysis of risk factors showed that only shift and length of time on hemodialysis were associated with HBV and HCV positivity, respectively. Among the four HBsAg-positive samples, HBV DNA was detected in three of them, which were identified as genotype A by restriction fragment length polymorphism (RFLP) analysis. All 14 HCV RNA-positive samples were genotyped by INNO-LiPA. Genotypes 1a and 3a were found in 85% and 15%, respectively. The present data show low HBsAg and HCV prevalence rates. The risk factors associated with HBV and HCV positivity suggest that nosocomial transmission may influence in spreading these viruses in the dialysis unit studied. |
| first_indexed | 2024-03-12T18:06:11Z |
| format | Article |
| id | doaj.art-29105267e360474891fb13a70084eaef |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:06:11Z |
| publishDate | 2003-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-29105267e360474891fb13a70084eaef2023-08-02T09:28:14ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602003-07-0198559960310.1590/S0074-02762003000500003<title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profilesKarla P SouzaJônio A LuzSheila A TelesMegmar AS CarneiroLuciana A OliveiraAdriane S GomesMárcia A DiasSelma A GomesClara FT YoshidaRegina MB MartinsA survey was conducted in the hemodialysis population of the state of Tocantins, Brazil, aiming to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, to analyze associated risk factors, and also to investigate these viruses genotypes distribution. During January and March 2001, all patients (n = 100) were interviewed at the unique dialysis unit in Tocantins. Blood samples were collected and serum samples were screened for HBV serological markers. Hepatitis B surface antigen positive samples were tested for HBV DNA. All samples were also tested for anti-HCV antibodies and HCV RNA. An overall prevalence of 45% was found for HBV infection (4% were HBsAg/anti-HBc positive, 2% were anti-HBc only and 39% had anti-HBc/anti-HBs markers). Concerning HCV infection, anti-HCV and HCV RNA were detected in 13% and 14% of the subjects, respectively. Three patients were HCV RNA positive and anti-HCV negative, resulting in an overall HCV prevalence of 16%. Univariate analysis of risk factors showed that only shift and length of time on hemodialysis were associated with HBV and HCV positivity, respectively. Among the four HBsAg-positive samples, HBV DNA was detected in three of them, which were identified as genotype A by restriction fragment length polymorphism (RFLP) analysis. All 14 HCV RNA-positive samples were genotyped by INNO-LiPA. Genotypes 1a and 3a were found in 85% and 15%, respectively. The present data show low HBsAg and HCV prevalence rates. The risk factors associated with HBV and HCV positivity suggest that nosocomial transmission may influence in spreading these viruses in the dialysis unit studied.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500003hepatitis B virushepatitis C virushemodialysisprevalencerisk factorsgenotypesTocantinsBrazil |
| spellingShingle | Karla P Souza Jônio A Luz Sheila A Teles Megmar AS Carneiro Luciana A Oliveira Adriane S Gomes Márcia A Dias Selma A Gomes Clara FT Yoshida Regina MB Martins <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles Memorias do Instituto Oswaldo Cruz hepatitis B virus hepatitis C virus hemodialysis prevalence risk factors genotypes Tocantins Brazil |
| title | <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles |
| title_full | <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles |
| title_fullStr | <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles |
| title_full_unstemmed | <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles |
| title_short | <title language="por">Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles |
| title_sort | title language por hepatitis b and c in the hemodialysis unit of tocantins brazil serological and molecular profiles |
| topic | hepatitis B virus hepatitis C virus hemodialysis prevalence risk factors genotypes Tocantins Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500003 |
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