Decitabine Promotes Modulation in Phenotype and Function of Monocytes and Macrophages That Drive Immune Response Regulation

Decitabine Promotes Modulation in Phenotype and Function of Monocytes and Macrophages That Drive Immune Response Regulation

Decitabine is an approved hypomethylating agent used for treating hematological malignancies. Although decitabine targets altered cells, epidrugs can trigger immunomodulatory effects, reinforcing the hypothesis of immunoregulation in treated patients. We therefore aimed to evaluate the impact of dec...

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Bibliographic Details
Main Authors: Fabiana Albani Zambuzi, Priscilla Mariane Cardoso-Silva, Ricardo Cardoso Castro, Caroline Fontanari, Flavio da Silva Emery, Fabiani Gai Frantz
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
DNMT inhibitors
phagocytosis
immune cell
monocyte/macrophages
Online Access:https://www.mdpi.com/2073-4409/10/4/868

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