Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison
The regeneration of bone is one of the main challenges of modern medicine because many diseases including trauma and tumor can cause bone defects. Tissue engineering (TE) is a promising approach to cure these bone diseases since it allows the reconstruction of tissue by colonization and proliferati...
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2015-05-01
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| Series: | Revista Facultad de Ingeniería Universidad de Antioquia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/ingenieria/article/view/20984 |
| _version_ | 1797861742618869760 |
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| author | Diana Marcela Escobar-Sierra Johan Martins Claudia Patricia Ossa-Orozco |
| author_facet | Diana Marcela Escobar-Sierra Johan Martins Claudia Patricia Ossa-Orozco |
| author_sort | Diana Marcela Escobar-Sierra |
| collection | DOAJ |
| description |
The regeneration of bone is one of the main challenges of modern medicine because many diseases including trauma and tumor can cause bone defects. Tissue engineering (TE) is a promising approach to cure these bone diseases since it allows the reconstruction of tissue by colonization and proliferation of a patient is healthy cells is in an artificial extracellular matrix (scaffolds). The aim of this project was to prepare chitosan/hydroxyapatite CH/HA scaffolds, using various ratios and two different methods: powder hydroxyapatite (commercial) and in situ hydroxyapatite, and then compare their properties. The morphology, chemical composition, and mechanical properties were evaluated by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy, and compression tests. The scaffolds obtained showed an interconnected porous structure. Scaffolds with better applications in tissue engineering are the scaffolds with chitosan and hydroxyapatite in situ protocol, due to their better morphology; they allow the cell growth. These scaffolds meet the requirements of tissue engineering.
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| first_indexed | 2024-04-09T22:08:01Z |
| format | Article |
| id | doaj.art-29109d87301f49fe99bfe64f10455011 |
| institution | Directory Open Access Journal |
| issn | 0120-6230 2422-2844 |
| language | English |
| last_indexed | 2024-04-09T22:08:01Z |
| publishDate | 2015-05-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Revista Facultad de Ingeniería Universidad de Antioquia |
| spelling | doaj.art-29109d87301f49fe99bfe64f104550112023-03-23T12:31:16ZengUniversidad de AntioquiaRevista Facultad de Ingeniería Universidad de Antioquia0120-62302422-28442015-05-017510.17533/udea.redin.n75a04Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparisonDiana Marcela Escobar-Sierra0Johan Martins1Claudia Patricia Ossa-Orozco2University of AntioquiaUniversity of Franche-ComteUniversity of Antioquia The regeneration of bone is one of the main challenges of modern medicine because many diseases including trauma and tumor can cause bone defects. Tissue engineering (TE) is a promising approach to cure these bone diseases since it allows the reconstruction of tissue by colonization and proliferation of a patient is healthy cells is in an artificial extracellular matrix (scaffolds). The aim of this project was to prepare chitosan/hydroxyapatite CH/HA scaffolds, using various ratios and two different methods: powder hydroxyapatite (commercial) and in situ hydroxyapatite, and then compare their properties. The morphology, chemical composition, and mechanical properties were evaluated by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy, and compression tests. The scaffolds obtained showed an interconnected porous structure. Scaffolds with better applications in tissue engineering are the scaffolds with chitosan and hydroxyapatite in situ protocol, due to their better morphology; they allow the cell growth. These scaffolds meet the requirements of tissue engineering. https://revistas.udea.edu.co/index.php/ingenieria/article/view/20984chitosanhydroxyapatite in situhydroxyapatite in powderscaffolds chitosan/ hydroxyapatitetissue engineeringbone |
| spellingShingle | Diana Marcela Escobar-Sierra Johan Martins Claudia Patricia Ossa-Orozco Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison Revista Facultad de Ingeniería Universidad de Antioquia chitosan hydroxyapatite in situ hydroxyapatite in powder scaffolds chitosan/ hydroxyapatite tissue engineering bone |
| title | Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| title_full | Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| title_fullStr | Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| title_full_unstemmed | Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| title_short | Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| title_sort | chitosan hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison |
| topic | chitosan hydroxyapatite in situ hydroxyapatite in powder scaffolds chitosan/ hydroxyapatite tissue engineering bone |
| url | https://revistas.udea.edu.co/index.php/ingenieria/article/view/20984 |
| work_keys_str_mv | AT dianamarcelaescobarsierra chitosanhydroxyapatitescaffoldsfortissueengineeringmanufacturingmethodeffectcomparison AT johanmartins chitosanhydroxyapatitescaffoldsfortissueengineeringmanufacturingmethodeffectcomparison AT claudiapatriciaossaorozco chitosanhydroxyapatitescaffoldsfortissueengineeringmanufacturingmethodeffectcomparison |