Hepatic pathology in Capillaria hepatica infected mice
Septal fibrosis of the liver regularly develops in rats infected with Capillaria hepatica. To find out whether such fibrosis also occurs in mice, 20 animals were submitted to infection with either 100 or 300 embryonated eggs and histologically examined after several periods of time, from 30 to 110 d...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2000-08-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000400002&tlng=en |
| _version_ | 1817978975916392448 |
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| author | Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Zilton A. Andrade |
| author_facet | Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Zilton A. Andrade |
| author_sort | Bruna Magalhães Gotardo |
| collection | DOAJ |
| description | Septal fibrosis of the liver regularly develops in rats infected with Capillaria hepatica. To find out whether such fibrosis also occurs in mice, 20 animals were submitted to infection with either 100 or 300 embryonated eggs and histologically examined after several periods of time, from 30 to 110 days afterwards. Results showed that mice developed acute, severe, diffuse and focal hepatic lesions that were soon modulated to focal areas of fibrosis containing eggs and worm remnants, despite the fact that a few worms remained alive, at least up to 110 days after inoculation. Areas of perisinusoidal fibrosis appeared in the proximity and around focal parasitic lesions, but clear-cut septal fibrosis was not observed. Why septal fibrosis forms in rats, but not in mice during C. hepatica infection, only further studies can clarify. Mice seem to show better host/parasite relationship than rats in regard to C. hepatica infection. |
| first_indexed | 2024-04-13T22:37:01Z |
| format | Article |
| id | doaj.art-29111eb37f45421cba01febd2ce0c655 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:37:01Z |
| publishDate | 2000-08-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-29111eb37f45421cba01febd2ce0c6552022-12-22T02:26:45ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492000-08-01334341346Hepatic pathology in Capillaria hepatica infected miceBruna Magalhães GotardoRodrigo Guimarães AndradeZilton A. Andrade0Fundação Instituto Oswaldo CruzSeptal fibrosis of the liver regularly develops in rats infected with Capillaria hepatica. To find out whether such fibrosis also occurs in mice, 20 animals were submitted to infection with either 100 or 300 embryonated eggs and histologically examined after several periods of time, from 30 to 110 days afterwards. Results showed that mice developed acute, severe, diffuse and focal hepatic lesions that were soon modulated to focal areas of fibrosis containing eggs and worm remnants, despite the fact that a few worms remained alive, at least up to 110 days after inoculation. Areas of perisinusoidal fibrosis appeared in the proximity and around focal parasitic lesions, but clear-cut septal fibrosis was not observed. Why septal fibrosis forms in rats, but not in mice during C. hepatica infection, only further studies can clarify. Mice seem to show better host/parasite relationship than rats in regard to C. hepatica infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000400002&tlng=enCapillaria hepaticaHepatic capillariasis in miceSeptal fibrosis |
| spellingShingle | Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Zilton A. Andrade Hepatic pathology in Capillaria hepatica infected mice Revista da Sociedade Brasileira de Medicina Tropical Capillaria hepatica Hepatic capillariasis in mice Septal fibrosis |
| title | Hepatic pathology in Capillaria hepatica infected mice |
| title_full | Hepatic pathology in Capillaria hepatica infected mice |
| title_fullStr | Hepatic pathology in Capillaria hepatica infected mice |
| title_full_unstemmed | Hepatic pathology in Capillaria hepatica infected mice |
| title_short | Hepatic pathology in Capillaria hepatica infected mice |
| title_sort | hepatic pathology in capillaria hepatica infected mice |
| topic | Capillaria hepatica Hepatic capillariasis in mice Septal fibrosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000400002&tlng=en |
| work_keys_str_mv | AT brunamagalhaesgotardo hepaticpathologyincapillariahepaticainfectedmice AT rodrigoguimaraesandrade hepaticpathologyincapillariahepaticainfectedmice AT ziltonaandrade hepaticpathologyincapillariahepaticainfectedmice |