NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma

Abstract Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a promising antitumor effect. However, the dysregulation of the redox system often causes radi...

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Bibliographic Details
Main Authors: Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang, Yi Ding
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medicine
Subjects:
NUPR1
Reactive oxygen species
Hepatocellular carcinoma
Radioresistance
Oxidative stress
Aryl hydrocarbon receptor
Online Access:https://doi.org/10.1186/s12916-022-02554-3

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