Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes

Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes

Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute and recurrent low glucose (RLG) exposure. The metab...

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Bibliographic Details
Main Authors: Paul G. Weightman Potter, Kate L. J. Ellacott, Andrew D. Randall, Craig Beall
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
astrocytes
hypoglycemia
diabetes mellitus
type 1
mitochondria
glycemic control
Online Access:https://www.mdpi.com/2073-4409/11/21/3422

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