Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome

Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome

Integrating functional data with GWAS loci can help interpret the function of genetic variants associated with disease. Here the authors map cis and trans methylation QTL in CD4 + T cells from patients and colocalize with GWAS loci in order to interpret genetic variants associated with multiple scle...

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Podrobná bibliografie
Hlavní autoři: Tina Roostaei, Hans-Ulrich Klein, Yiyi Ma, Daniel Felsky, Pia Kivisäkk, Sarah M. Connor, Alexandra Kroshilina, Christina Yung, Belinda J. Kaskow, Xiaorong Shao, Brooke Rhead, José M. Ordovás, Devin M. Absher, Donna K. Arnett, Jia Liu, Nikolaos Patsopoulos, Lisa F. Barcellos, Howard L. Weiner, Philip L. De Jager
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2021-12-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-021-27427-w

Internet

https://doi.org/10.1038/s41467-021-27427-w

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