Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Abstract Background Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver injury remains unclear. Thus, this study aimed to investigate the function...

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Bibliographic Details
Main Authors: Xiao-Xia Gu, Xiao-Xia Xu, Hui-Hua Liao, Ruo-Na Wu, Wei-Ming Huang, Li-Xia Cheng, Yi-Wen Lu, Jian Mo
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Inflammation
Subjects:
Dexmedetomidine hydrochloride
TUG1
SIRT1
miR-194
liver injury
Online Access:https://doi.org/10.1186/s12950-021-00287-3

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