Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis
ABSTRACT Objective: To explore the feasibility of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer. Materials and Methods: Embase, PubMed and Cochrane Library databases were searched for studies published before July 2020. The studies that used 68Ga-PSMA PET/CT for detecting primary prostate...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Urologia
2022-11-01
|
| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000600891&tlng=en |
| _version_ | 1798018859501879296 |
|---|---|
| author | Xianwen Hu Yan Wu Peiqing Yang Ju Wang Pan Wang Jiong Cai |
| author_facet | Xianwen Hu Yan Wu Peiqing Yang Ju Wang Pan Wang Jiong Cai |
| author_sort | Xianwen Hu |
| collection | DOAJ |
| description | ABSTRACT Objective: To explore the feasibility of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer. Materials and Methods: Embase, PubMed and Cochrane Library databases were searched for studies published before July 2020. The studies that used 68Ga-PSMA PET/CT for detecting primary prostate cancer, and pathological biopsy as the reference standard were included. The selecting process used preferred reporting items for systematic reviews and meta-analyses (PRISMA). The quality of enrolled studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Results: According to our search strategy, 9 studies were included for analysis. A total of 547 patients with primary prostate cancer and 443 lesion segments that underwent 68Ga-PSMA PET/CT scans were included and their pathological biopsies were compared. The results of these studies showed some differences. For instance, the lowest sensitivity of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer was 67%, while the highest sensitivity recorded was 97%. Conclusions: Compared with conventional imaging examinations, 68Ga-PSMA PET/CT had higher sensitivity and specificity in detecting primary prostate cancer. At present, most of the studies that used 68Ga-PSMA PET/CT for detecting prostate cancer are retrospective studies. Based on its advantage of high detection rate, the use of 68Ga-PSMA PET/CT in the detection of primary prostate cancer is worthy of promotion. |
| first_indexed | 2024-04-11T16:30:07Z |
| format | Article |
| id | doaj.art-29154c1827ee4047b48a07a4d37f8381 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-11T16:30:07Z |
| publishDate | 2022-11-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-29154c1827ee4047b48a07a4d37f83812022-12-22T04:14:02ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192022-11-0148689190210.1590/s1677-5538.ibju.2020.0986Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysisXianwen HuYan WuPeiqing YangJu WangPan WangJiong Caihttps://orcid.org/0000-0002-0185-445XABSTRACT Objective: To explore the feasibility of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer. Materials and Methods: Embase, PubMed and Cochrane Library databases were searched for studies published before July 2020. The studies that used 68Ga-PSMA PET/CT for detecting primary prostate cancer, and pathological biopsy as the reference standard were included. The selecting process used preferred reporting items for systematic reviews and meta-analyses (PRISMA). The quality of enrolled studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Results: According to our search strategy, 9 studies were included for analysis. A total of 547 patients with primary prostate cancer and 443 lesion segments that underwent 68Ga-PSMA PET/CT scans were included and their pathological biopsies were compared. The results of these studies showed some differences. For instance, the lowest sensitivity of 68Ga-PSMA PET/CT in diagnosing primary prostate cancer was 67%, while the highest sensitivity recorded was 97%. Conclusions: Compared with conventional imaging examinations, 68Ga-PSMA PET/CT had higher sensitivity and specificity in detecting primary prostate cancer. At present, most of the studies that used 68Ga-PSMA PET/CT for detecting prostate cancer are retrospective studies. Based on its advantage of high detection rate, the use of 68Ga-PSMA PET/CT in the detection of primary prostate cancer is worthy of promotion.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000600891&tlng=enProstate-Specific AntigenProstatic NeoplasmsPositron Emission Tomography Computed Tomography |
| spellingShingle | Xianwen Hu Yan Wu Peiqing Yang Ju Wang Pan Wang Jiong Cai Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis International Brazilian Journal of Urology Prostate-Specific Antigen Prostatic Neoplasms Positron Emission Tomography Computed Tomography |
| title | Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis |
| title_full | Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis |
| title_fullStr | Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis |
| title_short | Performance of 68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography/computed tomography in the diagnosis of primary prostate cancer: a systematic review and meta-analysis |
| title_sort | performance of 68ga labeled prostate specific membrane antigen ligand positron emission tomography computed tomography in the diagnosis of primary prostate cancer a systematic review and meta analysis |
| topic | Prostate-Specific Antigen Prostatic Neoplasms Positron Emission Tomography Computed Tomography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382022000600891&tlng=en |
| work_keys_str_mv | AT xianwenhu performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis AT yanwu performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis AT peiqingyang performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis AT juwang performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis AT panwang performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis AT jiongcai performanceof68galabeledprostatespecificmembraneantigenligandpositronemissiontomographycomputedtomographyinthediagnosisofprimaryprostatecancerasystematicreviewandmetaanalysis |