The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood

Epilepsy is an important health issue. The interest in ketogenic diet (KD) treatment in children and adolescents with drug-resistant epilepsy has increased in recent years. It was thought that KD was a last option of treatment in patients who were unresponsive to 2 or 3 anticonvulsant drugs. KD with...

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Main Authors: Gizem Özata Uyar, Nevin Şanlıer
Format: Article
Language:English
Published: Galenos Yayinevi 2018-09-01
Series:Türk Nöroloji Dergisi
Subjects:
Online Access:http://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-71473
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author Gizem Özata Uyar
Nevin Şanlıer
author_facet Gizem Özata Uyar
Nevin Şanlıer
author_sort Gizem Özata Uyar
collection DOAJ
description Epilepsy is an important health issue. The interest in ketogenic diet (KD) treatment in children and adolescents with drug-resistant epilepsy has increased in recent years. It was thought that KD was a last option of treatment in patients who were unresponsive to 2 or 3 anticonvulsant drugs. KD with limited protein, low carbohydrate, and high fat content was thought as a last option of treatment, previously. However, nowadays it is the most selected therapy worldwide in epileptic children and adolescents. Ketone bodies are elevated in the blood due to low carbohydrate and high lipid content of KD. Through the elevation of ketone bodies, the brain uses ketone bodies as energy sources, which results in decreased in epileptic seizures. Medical nutritional therapy during treatment of childhood epilepsies should also provide normal growth and development. For this reason, full compliance with the diet is important. The effect, place, and importance of ketogenic nutrition therapy in drug-resistant epilepsies of childhood are discussed in this review.
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spelling doaj.art-291562701dec4d8a9edd382da568f6842023-02-15T16:20:58ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X1309-25452018-09-0124321622510.4274/tnd.71473The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of ChildhoodGizem Özata Uyar0Nevin Şanlıer1Gazi University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, TurkeyGazi University Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, TurkeyEpilepsy is an important health issue. The interest in ketogenic diet (KD) treatment in children and adolescents with drug-resistant epilepsy has increased in recent years. It was thought that KD was a last option of treatment in patients who were unresponsive to 2 or 3 anticonvulsant drugs. KD with limited protein, low carbohydrate, and high fat content was thought as a last option of treatment, previously. However, nowadays it is the most selected therapy worldwide in epileptic children and adolescents. Ketone bodies are elevated in the blood due to low carbohydrate and high lipid content of KD. Through the elevation of ketone bodies, the brain uses ketone bodies as energy sources, which results in decreased in epileptic seizures. Medical nutritional therapy during treatment of childhood epilepsies should also provide normal growth and development. For this reason, full compliance with the diet is important. The effect, place, and importance of ketogenic nutrition therapy in drug-resistant epilepsies of childhood are discussed in this review.http://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-71473Childhooddrug-resistant epilepsyketogenic diet
spellingShingle Gizem Özata Uyar
Nevin Şanlıer
The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
Türk Nöroloji Dergisi
Childhood
drug-resistant epilepsy
ketogenic diet
title The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
title_full The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
title_fullStr The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
title_full_unstemmed The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
title_short The Effect of Ketogenic Diet Treatment in Drug-resistant Epilepsies of Childhood
title_sort effect of ketogenic diet treatment in drug resistant epilepsies of childhood
topic Childhood
drug-resistant epilepsy
ketogenic diet
url http://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-71473
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