The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can develop into hepatocellular carcinoma (HCC). The incidence of NAFLD-related HCC, which is accompanied by life-threatening complications, is increasing. Advanced fibrosis and lifestyle-related and meta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/3/516 |
| _version_ | 1797406088178434048 |
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| author | Tomomi Kogiso Katsutoshi Tokushige |
| author_facet | Tomomi Kogiso Katsutoshi Tokushige |
| author_sort | Tomomi Kogiso |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can develop into hepatocellular carcinoma (HCC). The incidence of NAFLD-related HCC, which is accompanied by life-threatening complications, is increasing. Advanced fibrosis and lifestyle-related and metabolic comorbidities, especially obesity and diabetes mellitus, are associated with HCC development. However, HCC is also observed in the non-cirrhotic liver. Often, diagnosis is delayed until the tumor is relatively large and the disease is advanced; an effective screening or surveillance method is urgently required. Recently, the NAFLD/nonalcoholic steatohepatitis (NASH) guidelines of Japan were revised to incorporate new strategies and evidence for the management and surveillance of NAFLD/NASH. Fibrosis must be tested for noninvasively, and the risk of carcinogenesis must be stratified. The treatment of lifestyle-related diseases is expected to reduce the incidence of NAFLD and prevent liver carcinogenesis. |
| first_indexed | 2024-03-09T03:20:06Z |
| format | Article |
| id | doaj.art-29163c890f6c4d54ae1ac0b12debf9d5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:20:06Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-29163c890f6c4d54ae1ac0b12debf9d52023-12-03T15:10:54ZengMDPI AGCancers2072-66942021-01-0113351610.3390/cancers13030516The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular CarcinomaTomomi Kogiso0Katsutoshi Tokushige1Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Internal Medicine, Institute of Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanNonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can develop into hepatocellular carcinoma (HCC). The incidence of NAFLD-related HCC, which is accompanied by life-threatening complications, is increasing. Advanced fibrosis and lifestyle-related and metabolic comorbidities, especially obesity and diabetes mellitus, are associated with HCC development. However, HCC is also observed in the non-cirrhotic liver. Often, diagnosis is delayed until the tumor is relatively large and the disease is advanced; an effective screening or surveillance method is urgently required. Recently, the NAFLD/nonalcoholic steatohepatitis (NASH) guidelines of Japan were revised to incorporate new strategies and evidence for the management and surveillance of NAFLD/NASH. Fibrosis must be tested for noninvasively, and the risk of carcinogenesis must be stratified. The treatment of lifestyle-related diseases is expected to reduce the incidence of NAFLD and prevent liver carcinogenesis.https://www.mdpi.com/2072-6694/13/3/516nonalcoholic fatty liver diseasehepatocellular carcinomaprevalenceprognosissurveillance |
| spellingShingle | Tomomi Kogiso Katsutoshi Tokushige The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma Cancers nonalcoholic fatty liver disease hepatocellular carcinoma prevalence prognosis surveillance |
| title | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma |
| title_full | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma |
| title_fullStr | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma |
| title_full_unstemmed | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma |
| title_short | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma |
| title_sort | current view of nonalcoholic fatty liver disease related hepatocellular carcinoma |
| topic | nonalcoholic fatty liver disease hepatocellular carcinoma prevalence prognosis surveillance |
| url | https://www.mdpi.com/2072-6694/13/3/516 |
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