Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment
<i>Background</i>: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. <i>Methods</i>: 203 study participants underwent whole-body MRI and pulmonary function t...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/8/2/46 |
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| author | Ricarda von Krüchten Susanne Rospleszcz Roberto Lorbeer Dunja Hasic Annette Peters Fabian Bamberg Holger Schulz Stefan Karrasch Christopher L. Schlett |
| author_facet | Ricarda von Krüchten Susanne Rospleszcz Roberto Lorbeer Dunja Hasic Annette Peters Fabian Bamberg Holger Schulz Stefan Karrasch Christopher L. Schlett |
| author_sort | Ricarda von Krüchten |
| collection | DOAJ |
| description | <i>Background</i>: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. <i>Methods</i>: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFF<sub>hepatic</sub>). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. <i>Results</i>: VAT (β = −0.13, <i>p</i> = 0.03) and SAT (β = −0.26, <i>p</i> < 0.001), but not PDFF<sub>hepatic</sub> were inversely associated with FEV1, while VAT (β = −0.27, <i>p</i> < 0.001), SAT (β = −0.41, <i>p</i> < 0.001), and PDFF<sub>hepatic</sub> (β = −0.17, <i>p</i> = 0.002) were inversely associated with FVC. PDFF<sub>hepatic</sub> was directly associated with the Tiffeneau index (β = 2.46, <i>p</i> < 0.001). <i>Conclusions</i>: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFF<sub>hepatic</sub> revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment. |
| first_indexed | 2024-03-09T10:27:54Z |
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| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-09T10:27:54Z |
| publishDate | 2022-02-01 |
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| spelling | doaj.art-291840f0b1b9438a87c446b61ba59f512023-12-01T21:29:05ZengMDPI AGTomography2379-13812379-139X2022-02-018256056910.3390/tomography8020046Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function ImpairmentRicarda von Krüchten0Susanne Rospleszcz1Roberto Lorbeer2Dunja Hasic3Annette Peters4Fabian Bamberg5Holger Schulz6Stefan Karrasch7Christopher L. Schlett8Department of Diagnostic and Interventional Radiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Radiology, Ludwig-Maximilians-University Hospital, 80336 Munich, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, GermanyInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyInstitute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-University, 81377 Munich, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany<i>Background</i>: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. <i>Methods</i>: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFF<sub>hepatic</sub>). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. <i>Results</i>: VAT (β = −0.13, <i>p</i> = 0.03) and SAT (β = −0.26, <i>p</i> < 0.001), but not PDFF<sub>hepatic</sub> were inversely associated with FEV1, while VAT (β = −0.27, <i>p</i> < 0.001), SAT (β = −0.41, <i>p</i> < 0.001), and PDFF<sub>hepatic</sub> (β = −0.17, <i>p</i> = 0.002) were inversely associated with FVC. PDFF<sub>hepatic</sub> was directly associated with the Tiffeneau index (β = 2.46, <i>p</i> < 0.001). <i>Conclusions</i>: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFF<sub>hepatic</sub> revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.https://www.mdpi.com/2379-139X/8/2/46respiratory function testslung diseasesabdominal fat depotshepatic fat contentmagnetic resonance imaging |
| spellingShingle | Ricarda von Krüchten Susanne Rospleszcz Roberto Lorbeer Dunja Hasic Annette Peters Fabian Bamberg Holger Schulz Stefan Karrasch Christopher L. Schlett Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment Tomography respiratory function tests lung diseases abdominal fat depots hepatic fat content magnetic resonance imaging |
| title | Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment |
| title_full | Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment |
| title_fullStr | Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment |
| title_full_unstemmed | Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment |
| title_short | Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment |
| title_sort | whole body mri derived adipose tissue characterization and relationship to pulmonary function impairment |
| topic | respiratory function tests lung diseases abdominal fat depots hepatic fat content magnetic resonance imaging |
| url | https://www.mdpi.com/2379-139X/8/2/46 |
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