Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs
Euphorbia hirta and Lactuca virosa are both powerful medicinal plants that are used in ethnomedicine to treat diarrhea, bacterial infections, inflammation, asthma, pain, fungus, cancer, and malaria.The aim of this study is to evaluate the antiasthmatic effect of the aqueous extracts of Lactuca viro...
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2024-01-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.ajol.info/index.php/jasem/article/view/262995 |
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| author | D. O. Uwaya I. E. Ogie O. G. Fayoriju E. G. Tafamel U. K. Obinna J. C. Atughara |
| author_facet | D. O. Uwaya I. E. Ogie O. G. Fayoriju E. G. Tafamel U. K. Obinna J. C. Atughara |
| author_sort | D. O. Uwaya |
| collection | DOAJ |
| description |
Euphorbia hirta and Lactuca virosa are both powerful medicinal plants that are used in ethnomedicine to treat diarrhea, bacterial infections, inflammation, asthma, pain, fungus, cancer, and malaria.The aim of this study is to evaluate the antiasthmatic effect of the aqueous extracts of Lactuca virosa and Euphorbia hirta on ovalbumin and ammonium hydroxide induced asthma in guinea pigs model using standard procedures after dividing animals into 8 groups of 4 animals each. Lungs and trachea were collected for histology. The result obtained shows that the leaves of Lactuca virosa and the whole plant of Euphorbia hirta increased the latency to preconvulsing time and reduced the trachea wall thickness when compared to the ovalbumin and aluminum hydroxide control (**p<0.01, *p<0.05). Hematology parameters were not affected (P<0.05). The extract increased the level of superoxide dismutase in the blood and tissues of the animals (P<0.01). Data obtained shows that the leaves of Lactuca virosa and the whole plant of Euphorbia hirta possess antiasthmatic properties.
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| first_indexed | 2024-04-24T18:51:25Z |
| format | Article |
| id | doaj.art-2918b65e0b814e8d96f1f54fc1b8f7cd |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T18:51:25Z |
| publishDate | 2024-01-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-2918b65e0b814e8d96f1f54fc1b8f7cd2024-03-26T20:08:06ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992024-01-0128110.4314/jasem.v28i1.8Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea PigsD. O. UwayaI. E. OgieO. G. FayorijuE. G. TafamelU. K. ObinnaJ. C. Atughara Euphorbia hirta and Lactuca virosa are both powerful medicinal plants that are used in ethnomedicine to treat diarrhea, bacterial infections, inflammation, asthma, pain, fungus, cancer, and malaria.The aim of this study is to evaluate the antiasthmatic effect of the aqueous extracts of Lactuca virosa and Euphorbia hirta on ovalbumin and ammonium hydroxide induced asthma in guinea pigs model using standard procedures after dividing animals into 8 groups of 4 animals each. Lungs and trachea were collected for histology. The result obtained shows that the leaves of Lactuca virosa and the whole plant of Euphorbia hirta increased the latency to preconvulsing time and reduced the trachea wall thickness when compared to the ovalbumin and aluminum hydroxide control (**p<0.01, *p<0.05). Hematology parameters were not affected (P<0.05). The extract increased the level of superoxide dismutase in the blood and tissues of the animals (P<0.01). Data obtained shows that the leaves of Lactuca virosa and the whole plant of Euphorbia hirta possess antiasthmatic properties. https://www.ajol.info/index.php/jasem/article/view/262995Euphorbia hirta; Lactuca virosa; antiasthmatic; asthma; ovalbumin |
| spellingShingle | D. O. Uwaya I. E. Ogie O. G. Fayoriju E. G. Tafamel U. K. Obinna J. C. Atughara Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs Journal of Applied Sciences and Environmental Management Euphorbia hirta; Lactuca virosa; antiasthmatic; asthma; ovalbumin |
| title | Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs |
| title_full | Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs |
| title_fullStr | Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs |
| title_full_unstemmed | Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs |
| title_short | Evaluation of Antiasthmatic Effect of Aqueous Extract of Euphorbia Hirta and Lactuca Virosa on Ovalbumin and Ammonium Hydroxide Induced Asthma in Guinea Pigs |
| title_sort | evaluation of antiasthmatic effect of aqueous extract of euphorbia hirta and lactuca virosa on ovalbumin and ammonium hydroxide induced asthma in guinea pigs |
| topic | Euphorbia hirta; Lactuca virosa; antiasthmatic; asthma; ovalbumin |
| url | https://www.ajol.info/index.php/jasem/article/view/262995 |
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