Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Abstract Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β‐amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi-IET
2023-05-01
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| Series: | IET Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1049/nbt2.12127 |
| _version_ | 1797419830267084800 |
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| author | Cyrus Jalili Amir Kiani Mohammadreza Gholami Fariborz Bahrehmand Sajad Fakhri Somayeh Kakehbaraei Seyran Kakebaraei |
| author_facet | Cyrus Jalili Amir Kiani Mohammadreza Gholami Fariborz Bahrehmand Sajad Fakhri Somayeh Kakehbaraei Seyran Kakebaraei |
| author_sort | Cyrus Jalili |
| collection | DOAJ |
| description | Abstract Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β‐amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are among the major signs of AD. Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). Investigations have shown the neuroprotective action of RES. This compound can be encapsulated by several methods (e.g. polymeric nanoparticles (NPs), solid lipid nanoparticles, Micelles, and liposomes). This antioxidant compound, however, barely crosses the blood–brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain. Thanks to nanotechnology, the efficiency of AD therapy can be improved by encapsulating the drugs in a NP with a controlled size (1–100 nm). This article addressed the use of RES, as a Phytobioactive compound, to decrease the oxidative stress. Encapsulation of this compound in the form of nanocarriers to treat neurological diseases to improve BBB crossing is also discussed. |
| first_indexed | 2024-03-09T06:53:57Z |
| format | Article |
| id | doaj.art-2918b67dd23d4c80b87e227115a5f23b |
| institution | Directory Open Access Journal |
| issn | 1751-8741 1751-875X |
| language | English |
| last_indexed | 2024-03-09T06:53:57Z |
| publishDate | 2023-05-01 |
| publisher | Hindawi-IET |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj.art-2918b67dd23d4c80b87e227115a5f23b2023-12-03T10:11:20ZengHindawi-IETIET Nanobiotechnology1751-87411751-875X2023-05-0117315417010.1049/nbt2.12127Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A reviewCyrus Jalili0Amir Kiani1Mohammadreza Gholami2Fariborz Bahrehmand3Sajad Fakhri4Somayeh Kakehbaraei5Seyran Kakebaraei6Medical Biology Research Center Research Institute for Health Technology Kermanshah University of Medical Sciences Kermanshah IranRegenerative Medicine Research Center Research Institute for Health Technology Kermanshah University of Medical Sciences Kermanshah IranDepartment of Anatomical Sciences Kermanshah University of Medical Sciences Kermanshah IranMedical Biology Research Center Research Institute for Health Technology Kermanshah University of Medical Sciences Kermanshah IranPharmaceutical Sciences Research Center Health Institute Kermanshah University of Medical Sciences Kermanshah IranStudent Research Committee Tabriz University of Medical Sciences Tabriz IranFaculty Anatomy Students Research Committee Kermanshah University of Medical Sciences Kermanshah IranAbstract Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β‐amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are among the major signs of AD. Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). Investigations have shown the neuroprotective action of RES. This compound can be encapsulated by several methods (e.g. polymeric nanoparticles (NPs), solid lipid nanoparticles, Micelles, and liposomes). This antioxidant compound, however, barely crosses the blood–brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain. Thanks to nanotechnology, the efficiency of AD therapy can be improved by encapsulating the drugs in a NP with a controlled size (1–100 nm). This article addressed the use of RES, as a Phytobioactive compound, to decrease the oxidative stress. Encapsulation of this compound in the form of nanocarriers to treat neurological diseases to improve BBB crossing is also discussed.https://doi.org/10.1049/nbt2.12127β‐amyloidAlzheimer’s diseaseNanoparticlesNeuroinflammationResveratrol |
| spellingShingle | Cyrus Jalili Amir Kiani Mohammadreza Gholami Fariborz Bahrehmand Sajad Fakhri Somayeh Kakehbaraei Seyran Kakebaraei Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review IET Nanobiotechnology β‐amyloid Alzheimer’s disease Nanoparticles Neuroinflammation Resveratrol |
| title | Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review |
| title_full | Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review |
| title_fullStr | Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review |
| title_full_unstemmed | Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review |
| title_short | Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review |
| title_sort | brain targeting based nanocarriers loaded with resveratrol in alzheimer s disease a review |
| topic | β‐amyloid Alzheimer’s disease Nanoparticles Neuroinflammation Resveratrol |
| url | https://doi.org/10.1049/nbt2.12127 |
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