Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula
Summary: The anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004218301469 |
| _version_ | 1818960734092001280 |
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| author | Jinjian Huang Zongan Li Qiongyuan Hu Guopu Chen Yanhan Ren Xiuwen Wu Jianan Ren |
| author_facet | Jinjian Huang Zongan Li Qiongyuan Hu Guopu Chen Yanhan Ren Xiuwen Wu Jianan Ren |
| author_sort | Jinjian Huang |
| collection | DOAJ |
| description | Summary: The anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl methacrylate-modified xanthan. This newly synthesized hydrogel exhibited a specific concentration-dependent porosity, swelling ratio, and stiffness. The intestinal epithelial cells-6 could grow on the surface of the stiffer hydrogel, and achieved their gut barrier functions. A simulated gut microfluidic chip was manufactured to demonstrate the hydrogel's good performance of anti-digestion compared with the current product, fibrin sealant. Furthermore, calcium ions could induce the swelling-shrinking behavior of the hydrogel, which assisted in removing the hydrogels at the proper time so as to avoid the mismatch of hydrogel degradation and tissue regeneration. Therefore, this hydrogel is expected to be an outstanding gut repair material, especially for closing gastrointestinal fistula. : Surgery; Polymers; Biomaterials; Biomedical Materials Subject Areas: Surgery, Polymers, Biomaterials, Biomedical Materials |
| first_indexed | 2024-12-20T12:02:14Z |
| format | Article |
| id | doaj.art-291d1c0676af4a70894c941c1377665e |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-20T12:02:14Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-291d1c0676af4a70894c941c1377665e2022-12-21T19:41:30ZengElsevieriScience2589-00422018-10-0184048Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal FistulaJinjian Huang0Zongan Li1Qiongyuan Hu2Guopu Chen3Yanhan Ren4Xiuwen Wu5Jianan Ren6School of Medicine, Southeast University, Nanjing, China; Lab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, ChinaNARI School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, ChinaLab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, ChinaLab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, ChinaChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USALab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, ChinaSchool of Medicine, Southeast University, Nanjing, China; Lab for Trauma and Surgical Infections, Department of Surgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, China; Corresponding authorSummary: The anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl methacrylate-modified xanthan. This newly synthesized hydrogel exhibited a specific concentration-dependent porosity, swelling ratio, and stiffness. The intestinal epithelial cells-6 could grow on the surface of the stiffer hydrogel, and achieved their gut barrier functions. A simulated gut microfluidic chip was manufactured to demonstrate the hydrogel's good performance of anti-digestion compared with the current product, fibrin sealant. Furthermore, calcium ions could induce the swelling-shrinking behavior of the hydrogel, which assisted in removing the hydrogels at the proper time so as to avoid the mismatch of hydrogel degradation and tissue regeneration. Therefore, this hydrogel is expected to be an outstanding gut repair material, especially for closing gastrointestinal fistula. : Surgery; Polymers; Biomaterials; Biomedical Materials Subject Areas: Surgery, Polymers, Biomaterials, Biomedical Materialshttp://www.sciencedirect.com/science/article/pii/S2589004218301469 |
| spellingShingle | Jinjian Huang Zongan Li Qiongyuan Hu Guopu Chen Yanhan Ren Xiuwen Wu Jianan Ren Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula iScience |
| title | Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula |
| title_full | Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula |
| title_fullStr | Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula |
| title_full_unstemmed | Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula |
| title_short | Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula |
| title_sort | bioinspired anti digestive hydrogels selected by a simulated gut microfluidic chip for closing gastrointestinal fistula |
| url | http://www.sciencedirect.com/science/article/pii/S2589004218301469 |
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