Antenna Mechanism of Length Control of Actin Cables.
Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the ba...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-06-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC4480850?pdf=render |
| _version_ | 1811268562353913856 |
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| author | Lishibanya Mohapatra Bruce L Goode Jane Kondev |
| author_facet | Lishibanya Mohapatra Bruce L Goode Jane Kondev |
| author_sort | Lishibanya Mohapatra |
| collection | DOAJ |
| description | Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This "antenna mechanism" involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentration of myosin motors delivering Smy1. These results provide testable predictions of the antenna mechanism of actin-cable length control. |
| first_indexed | 2024-04-12T21:24:27Z |
| format | Article |
| id | doaj.art-291d337c947f498aa65c27bc89664c5b |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-12T21:24:27Z |
| publishDate | 2015-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-291d337c947f498aa65c27bc89664c5b2022-12-22T03:16:12ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582015-06-01116e100416010.1371/journal.pcbi.1004160Antenna Mechanism of Length Control of Actin Cables.Lishibanya MohapatraBruce L GoodeJane KondevActin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This "antenna mechanism" involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentration of myosin motors delivering Smy1. These results provide testable predictions of the antenna mechanism of actin-cable length control.http://europepmc.org/articles/PMC4480850?pdf=render |
| spellingShingle | Lishibanya Mohapatra Bruce L Goode Jane Kondev Antenna Mechanism of Length Control of Actin Cables. PLoS Computational Biology |
| title | Antenna Mechanism of Length Control of Actin Cables. |
| title_full | Antenna Mechanism of Length Control of Actin Cables. |
| title_fullStr | Antenna Mechanism of Length Control of Actin Cables. |
| title_full_unstemmed | Antenna Mechanism of Length Control of Actin Cables. |
| title_short | Antenna Mechanism of Length Control of Actin Cables. |
| title_sort | antenna mechanism of length control of actin cables |
| url | http://europepmc.org/articles/PMC4480850?pdf=render |
| work_keys_str_mv | AT lishibanyamohapatra antennamechanismoflengthcontrolofactincables AT brucelgoode antennamechanismoflengthcontrolofactincables AT janekondev antennamechanismoflengthcontrolofactincables |