Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

Approximately one out of every ten cases of epithelial ovarian cancer (EOC) is inherited. The majority of inherited cases of EOC result from mutations in the breast cancer associated gene 1 (BRCA1). In addition to mutation of BRCA1, mutation of the p53 gene is often found in patients with inherited...

Full description

Bibliographic Details
Main Authors: Bridget A Quinn, Tiffany Brake, Xiang Hua, Kimberly Baxter-Jones, Samuel Litwin, Lora Hedrick Ellenson, Denise C Connolly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2796165?pdf=render

Internet

http://europepmc.org/articles/PMC2796165?pdf=render

Similar Items