Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan
The oral food challenge test (OFC) is the gold standard for evaluating the remission of food protein-induced enterocolitis syndrome (FPIES). Few acute FPIES remissions confirmed by OFC were reported. This study aimed to examine the OFC for Japanese children with acute FPIES to evaluate its remission...
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/19/4158 |
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| author | Koji Nishimura Kiwako Yamamoto-Hanada Miori Sato Kenji Toyokuni Hiroya Ogita Tomoyuki Kiguchi Yoshitsune Miyagi Yusuke Inuzuka Mayako Saito-Abe Makoto Irahara Fumi Ishikawa Shigenori Kabashima Yumiko Miyaji Tatsuki Fukuie Ichiro Nomura Yukihiro Ohya |
| author_facet | Koji Nishimura Kiwako Yamamoto-Hanada Miori Sato Kenji Toyokuni Hiroya Ogita Tomoyuki Kiguchi Yoshitsune Miyagi Yusuke Inuzuka Mayako Saito-Abe Makoto Irahara Fumi Ishikawa Shigenori Kabashima Yumiko Miyaji Tatsuki Fukuie Ichiro Nomura Yukihiro Ohya |
| author_sort | Koji Nishimura |
| collection | DOAJ |
| description | The oral food challenge test (OFC) is the gold standard for evaluating the remission of food protein-induced enterocolitis syndrome (FPIES). Few acute FPIES remissions confirmed by OFC were reported. This study aimed to examine the OFC for Japanese children with acute FPIES to evaluate its remission. A retrospective cohort study was performed on children with acute FPIES with remission evaluation by OFC based on one food challenge dose (1/50, 1/10, 1/2, and full dose per day). Acute FPIES remission was observed in 65.2% of patients (15/23 patients). Vomiting episodes occurred with 1/50 full doses on the first day among 75% of positive patients. The median duration between the onset and OFC was 14 months (IQR, 8–24 months). Soy was the most common causative food, followed by egg yolk, milk, and wheat. All patients could receive OFC safely without intensive care unit care, based on the FPIES OFC protocol. The remission rate of acute FPIES was high. However, vomiting episodes commonly occurred with 1/50 full doses on the first day. This study suggested that our OFC protocol for acute FPIES was safe and feasible, but it might be safer for some patients to start at a minimal loading dose. |
| first_indexed | 2024-03-09T21:18:36Z |
| format | Article |
| id | doaj.art-291f1ce99f924e14a572ccae15f0f257 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T21:18:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-291f1ce99f924e14a572ccae15f0f2572023-11-23T21:26:36ZengMDPI AGNutrients2072-66432022-10-011419415810.3390/nu14194158Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in JapanKoji Nishimura0Kiwako Yamamoto-Hanada1Miori Sato2Kenji Toyokuni3Hiroya Ogita4Tomoyuki Kiguchi5Yoshitsune Miyagi6Yusuke Inuzuka7Mayako Saito-Abe8Makoto Irahara9Fumi Ishikawa10Shigenori Kabashima11Yumiko Miyaji12Tatsuki Fukuie13Ichiro Nomura14Yukihiro Ohya15Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanThe oral food challenge test (OFC) is the gold standard for evaluating the remission of food protein-induced enterocolitis syndrome (FPIES). Few acute FPIES remissions confirmed by OFC were reported. This study aimed to examine the OFC for Japanese children with acute FPIES to evaluate its remission. A retrospective cohort study was performed on children with acute FPIES with remission evaluation by OFC based on one food challenge dose (1/50, 1/10, 1/2, and full dose per day). Acute FPIES remission was observed in 65.2% of patients (15/23 patients). Vomiting episodes occurred with 1/50 full doses on the first day among 75% of positive patients. The median duration between the onset and OFC was 14 months (IQR, 8–24 months). Soy was the most common causative food, followed by egg yolk, milk, and wheat. All patients could receive OFC safely without intensive care unit care, based on the FPIES OFC protocol. The remission rate of acute FPIES was high. However, vomiting episodes commonly occurred with 1/50 full doses on the first day. This study suggested that our OFC protocol for acute FPIES was safe and feasible, but it might be safer for some patients to start at a minimal loading dose.https://www.mdpi.com/2072-6643/14/19/4158allergensdietary proteinsenterocolitisfood hypersensitivityimmune tolerance |
| spellingShingle | Koji Nishimura Kiwako Yamamoto-Hanada Miori Sato Kenji Toyokuni Hiroya Ogita Tomoyuki Kiguchi Yoshitsune Miyagi Yusuke Inuzuka Mayako Saito-Abe Makoto Irahara Fumi Ishikawa Shigenori Kabashima Yumiko Miyaji Tatsuki Fukuie Ichiro Nomura Yukihiro Ohya Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan Nutrients allergens dietary proteins enterocolitis food hypersensitivity immune tolerance |
| title | Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan |
| title_full | Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan |
| title_fullStr | Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan |
| title_full_unstemmed | Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan |
| title_short | Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan |
| title_sort | remission of acute food protein induced enterocolitis syndrome confirmed by oral food challenges in japan |
| topic | allergens dietary proteins enterocolitis food hypersensitivity immune tolerance |
| url | https://www.mdpi.com/2072-6643/14/19/4158 |
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