Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients
Objective: To investigate the relation involving soluble interleukin-2 receptor, interleukin-6 and interleukin-10 in hospitalised patients with severe coronavirus disease-2019 infection. Methods: This single-centre cohort study was conducted at the Kafrelshiekh University Hospital, Egypt, from Janu...
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| Format: | Article |
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Pakistan Medical Association
2023-05-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://ojs.jpma.org.pk/index.php/public_html/article/view/9851 |
| _version_ | 1797812077670170624 |
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| author | Asmaa Embarak Hassan Nahla Abdelaziz Nosair Mohammed Hussien Ahmed Dalia Elsayed Sherif Eman Mohammad Habib Nahla Farahat |
| author_facet | Asmaa Embarak Hassan Nahla Abdelaziz Nosair Mohammed Hussien Ahmed Dalia Elsayed Sherif Eman Mohammad Habib Nahla Farahat |
| author_sort | Asmaa Embarak Hassan |
| collection | DOAJ |
| description |
Objective: To investigate the relation involving soluble interleukin-2 receptor, interleukin-6 and interleukin-10 in hospitalised patients with severe coronavirus disease-2019 infection.
Methods: This single-centre cohort study was conducted at the Kafrelshiekh University Hospital, Egypt, from January to June 2022, and included all patients of either gender who were hospitalised with severe infection with the coronavirus disease-2019 isolation ward. Chemiluminescence immunoassay method was used to measure levels of procalcitonin, ferritin, soluble interleukin-2 receptor, interleukin-6 and interleukin-10. Data was analysed using SPSS version. 25
Results: Of the 250 patients with median age 57.5 years (interquartile range: 45.8-66.0 years), 147(59%) were males and 103(41%) were females. Of them, 102(40.8%) patients died; 68(66.7%) males, 34(33.3%) females, median age 60.0 years (interquartile range: 48.8-70.0). Among the 148(59.2%) survivors, 79(53.4%) were males and 69(46.6%) were females, while the overall median age was 55.0 years (interquartile range: 41.5-65.8 years). The survivors had significantly lower levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 (p<0.001). Correlation analysis identified significant positive correlation between IL-2R, IL-6 and IL-10 levels and almost all the inflammatory
and coagulation parameters, including C-reactive protein, lactate dehydrogenase, procalcitonin, ferritin, D-dimer and fibrinogen (p<0.05).
Conclusion: Elevated levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 were found to be associated with greater risk of mortality in coronavirus disease-2019 patients.
Keywords: Interleukin-6, Interleukin-10, Procalcitonin, Fibrin fragment D, COVID-19, Luminescence, Interleukin-2, Immunoassay, Fibrinogen, Ferritins
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| first_indexed | 2024-03-13T07:33:12Z |
| format | Article |
| id | doaj.art-29214b2b5ad64f219569df43a8545b41 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T07:33:12Z |
| publishDate | 2023-05-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-29214b2b5ad64f219569df43a8545b412023-06-04T04:23:18ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-05-0173410.47391/JPMA.EGY-S4-36Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patientsAsmaa Embarak Hassan0Nahla Abdelaziz Nosair1Mohammed Hussien Ahmed2Dalia Elsayed Sherif3Eman Mohammad Habib4Nahla Farahat5Department of Clinical Pathology, Kafrelsheikh University, Egypt.Department of Clinical Pathology, Kafrelsheikh University, EgyptDepartment of Internal Medicine and Gastroenterology, Kafrelsheikh University, Egypt.Department of Clinical Pathology, Kafrelsheikh University, EgyptDepartment of Clinical Pathology, Kafrelsheikh University, EgyptDepartment of Clinical Pathology, Alexandria University, Alexandria, Egypt Objective: To investigate the relation involving soluble interleukin-2 receptor, interleukin-6 and interleukin-10 in hospitalised patients with severe coronavirus disease-2019 infection. Methods: This single-centre cohort study was conducted at the Kafrelshiekh University Hospital, Egypt, from January to June 2022, and included all patients of either gender who were hospitalised with severe infection with the coronavirus disease-2019 isolation ward. Chemiluminescence immunoassay method was used to measure levels of procalcitonin, ferritin, soluble interleukin-2 receptor, interleukin-6 and interleukin-10. Data was analysed using SPSS version. 25 Results: Of the 250 patients with median age 57.5 years (interquartile range: 45.8-66.0 years), 147(59%) were males and 103(41%) were females. Of them, 102(40.8%) patients died; 68(66.7%) males, 34(33.3%) females, median age 60.0 years (interquartile range: 48.8-70.0). Among the 148(59.2%) survivors, 79(53.4%) were males and 69(46.6%) were females, while the overall median age was 55.0 years (interquartile range: 41.5-65.8 years). The survivors had significantly lower levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 (p<0.001). Correlation analysis identified significant positive correlation between IL-2R, IL-6 and IL-10 levels and almost all the inflammatory and coagulation parameters, including C-reactive protein, lactate dehydrogenase, procalcitonin, ferritin, D-dimer and fibrinogen (p<0.05). Conclusion: Elevated levels of soluble interleukin-2 receptor, interleukin-6 and interleukin-10 were found to be associated with greater risk of mortality in coronavirus disease-2019 patients. Keywords: Interleukin-6, Interleukin-10, Procalcitonin, Fibrin fragment D, COVID-19, Luminescence, Interleukin-2, Immunoassay, Fibrinogen, Ferritins https://ojs.jpma.org.pk/index.php/public_html/article/view/9851Interleukin-6Interleukin-10ProcalcitoninFibrin fragment DCOVID-19Luminescence |
| spellingShingle | Asmaa Embarak Hassan Nahla Abdelaziz Nosair Mohammed Hussien Ahmed Dalia Elsayed Sherif Eman Mohammad Habib Nahla Farahat Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients Journal of the Pakistan Medical Association Interleukin-6 Interleukin-10 Procalcitonin Fibrin fragment D COVID-19 Luminescence |
| title | Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients |
| title_full | Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients |
| title_fullStr | Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients |
| title_full_unstemmed | Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients |
| title_short | Relation between Interleukin-6, Interleukin-10 and Interleukin-2 Receptor and mortality in Severely Ill COVID-19 patients |
| title_sort | relation between interleukin 6 interleukin 10 and interleukin 2 receptor and mortality in severely ill covid 19 patients |
| topic | Interleukin-6 Interleukin-10 Procalcitonin Fibrin fragment D COVID-19 Luminescence |
| url | https://ojs.jpma.org.pk/index.php/public_html/article/view/9851 |
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