Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series
Abstract Introduction The purpose of this study was to report the success and long-term outcomes of cyanoacrylate tissue adhesive (CTA) application in the management of corneal perforation disorders. Methods This retrospective case series describes the profile and outcomes of eyes that underwent CTA...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-08-01
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| Series: | Ophthalmology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40123-023-00785-y |
| _version_ | 1797630360027136000 |
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| author | Salman N. Sadiq Cristian Cartes Muhammad N. Sarfraz Francisco C. Figueiredo |
| author_facet | Salman N. Sadiq Cristian Cartes Muhammad N. Sarfraz Francisco C. Figueiredo |
| author_sort | Salman N. Sadiq |
| collection | DOAJ |
| description | Abstract Introduction The purpose of this study was to report the success and long-term outcomes of cyanoacrylate tissue adhesive (CTA) application in the management of corneal perforation disorders. Methods This retrospective case series describes the profile and outcomes of eyes that underwent CTA for corneal perforation over an 11-year period from January 2009 until January 2020 at a tertiary eye centre in the United Kingdom. Results In total, 25 eyes underwent CTA application during the study period. Non-traumatic sterile corneal melt was responsible in more than half of the cases (56.0%; n = 14) followed by infection (32.0%; n = 8) and trauma (12.0%; n = 3). Median size of perforation was 2.0 mm (interquartile range, IQR 1.0–3.0). The most common anatomical location of corneal perforation was central (56.0%; n = 14). Ocular surface disease was seen in almost all eyes except two (92.0%; n = 23) with dry eye disease being the most common (48.0%; n = 12). Amongst 23 eyes that completed follow-up (median 27 months; IQR 9.5–46.5), single CTA application was successful in achieving intact globe in 13 (56.5%) eyes and repeat gluing sealed total of 20 (86.9%) eyes. Survival analysis showed cumulative success of 71.0% and 51.2% at 90 and 250 days, respectively. The CTA was retained in the eyes for median of 94.0 days (IQR 30.0–140.5). A total of five patients developed adverse events, including endophthalmitis (n = 2), following CTA application. Conclusions CTA was highly effective in sealing corneal perforations in acute setting and showed moderate long-term success. However, multiple applications are often required. |
| first_indexed | 2024-03-11T11:07:16Z |
| format | Article |
| id | doaj.art-2921c1fcb9024372bb68c5d79e64063c |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-03-11T11:07:16Z |
| publishDate | 2023-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-2921c1fcb9024372bb68c5d79e64063c2023-11-12T12:08:58ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-08-011263403341310.1007/s40123-023-00785-yOutcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case SeriesSalman N. Sadiq0Cristian Cartes1Muhammad N. Sarfraz2Francisco C. Figueiredo3Royal Victoria InfirmaryRoyal Victoria InfirmaryRoyal Victoria InfirmaryRoyal Victoria InfirmaryAbstract Introduction The purpose of this study was to report the success and long-term outcomes of cyanoacrylate tissue adhesive (CTA) application in the management of corneal perforation disorders. Methods This retrospective case series describes the profile and outcomes of eyes that underwent CTA for corneal perforation over an 11-year period from January 2009 until January 2020 at a tertiary eye centre in the United Kingdom. Results In total, 25 eyes underwent CTA application during the study period. Non-traumatic sterile corneal melt was responsible in more than half of the cases (56.0%; n = 14) followed by infection (32.0%; n = 8) and trauma (12.0%; n = 3). Median size of perforation was 2.0 mm (interquartile range, IQR 1.0–3.0). The most common anatomical location of corneal perforation was central (56.0%; n = 14). Ocular surface disease was seen in almost all eyes except two (92.0%; n = 23) with dry eye disease being the most common (48.0%; n = 12). Amongst 23 eyes that completed follow-up (median 27 months; IQR 9.5–46.5), single CTA application was successful in achieving intact globe in 13 (56.5%) eyes and repeat gluing sealed total of 20 (86.9%) eyes. Survival analysis showed cumulative success of 71.0% and 51.2% at 90 and 250 days, respectively. The CTA was retained in the eyes for median of 94.0 days (IQR 30.0–140.5). A total of five patients developed adverse events, including endophthalmitis (n = 2), following CTA application. Conclusions CTA was highly effective in sealing corneal perforations in acute setting and showed moderate long-term success. However, multiple applications are often required.https://doi.org/10.1007/s40123-023-00785-yCyanoacrylateCorneal perforationOutcomesTissue adhesive |
| spellingShingle | Salman N. Sadiq Cristian Cartes Muhammad N. Sarfraz Francisco C. Figueiredo Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series Ophthalmology and Therapy Cyanoacrylate Corneal perforation Outcomes Tissue adhesive |
| title | Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series |
| title_full | Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series |
| title_fullStr | Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series |
| title_full_unstemmed | Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series |
| title_short | Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series |
| title_sort | outcomes of n butyl 2 cyanoacrylate tissue adhesive application in corneal perforation disorders consecutive case series |
| topic | Cyanoacrylate Corneal perforation Outcomes Tissue adhesive |
| url | https://doi.org/10.1007/s40123-023-00785-y |
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