Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018
ABSTRACTThe growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxon...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1681242 |
| _version_ | 1827579234167554048 |
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| author | Qianqin Yuan Yamei Li Leshan Xiu Chi Zhang Yaoyang Fu Chuanhao Jiang Lingli Tang Junping Peng |
| author_facet | Qianqin Yuan Yamei Li Leshan Xiu Chi Zhang Yaoyang Fu Chuanhao Jiang Lingli Tang Junping Peng |
| author_sort | Qianqin Yuan |
| collection | DOAJ |
| description | ABSTRACTThe growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance. |
| first_indexed | 2024-03-08T21:58:45Z |
| format | Article |
| id | doaj.art-2921ce168b61451bab9d433e80a71875 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:58:45Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-2921ce168b61451bab9d433e80a718752023-12-19T16:09:58ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811546154910.1080/22221751.2019.1681242Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018Qianqin Yuan0Yamei Li1Leshan Xiu2Chi Zhang3Yaoyang Fu4Chuanhao Jiang5Lingli Tang6Junping Peng7Department of Laboratory Medicine, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaNational Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaNational Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaNational Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaDepartment of Laboratory Medicine, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaDepartment of Laboratory Medicine, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaDepartment of Laboratory Medicine, the Second Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaNational Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaABSTRACTThe growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic penA-60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant N. gonorrhoeae FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance.https://www.tandfonline.com/doi/10.1080/22221751.2019.1681242Neisseria gonorrhoeaemultidrug-resistantceftriaxoneazithromycinphylogeny |
| spellingShingle | Qianqin Yuan Yamei Li Leshan Xiu Chi Zhang Yaoyang Fu Chuanhao Jiang Lingli Tang Junping Peng Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 Emerging Microbes and Infections Neisseria gonorrhoeae multidrug-resistant ceftriaxone azithromycin phylogeny |
| title | Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 |
| title_full | Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 |
| title_fullStr | Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 |
| title_full_unstemmed | Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 |
| title_short | Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 |
| title_sort | identification of multidrug resistant neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin china 2017 2018 |
| topic | Neisseria gonorrhoeae multidrug-resistant ceftriaxone azithromycin phylogeny |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1681242 |
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