Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy
This study retrospectively reviewed data from men with localized prostate cancer treated with external beam radiotherapy (EBRT). We identified 359 men with localized prostate cancer treated with curative EBRT at the Cross Cancer Institute between 2010–2011. The volume of seminal vesicles (SVs) treat...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/7/483 |
| _version_ | 1797589643608195072 |
|---|---|
| author | Tanner Steed Nikki Chopra Jihyun Yun Jordan Hill Benjamin Burke Sunita Ghosh Brad Warkentin Nawaid Usmani |
| author_facet | Tanner Steed Nikki Chopra Jihyun Yun Jordan Hill Benjamin Burke Sunita Ghosh Brad Warkentin Nawaid Usmani |
| author_sort | Tanner Steed |
| collection | DOAJ |
| description | This study retrospectively reviewed data from men with localized prostate cancer treated with external beam radiotherapy (EBRT). We identified 359 men with localized prostate cancer treated with curative EBRT at the Cross Cancer Institute between 2010–2011. The volume of seminal vesicles (SVs) treated as well as dose values were extracted. These volumes were compared to gold standard contours drawn by a trained expert based on consensus European Society for Radiotherapy and Oncology (ESTRO) contouring guidelines. Patient and tumor characteristics were extracted for these patients. Memorial Sloan Kettering prostate cancer nomogram was used to assign a predicted risk of SV involvement for each patient based on baseline tumor characteristics. In patients with a predicted risk of SV involvement greater than 15% (<i>n</i> = 184), 86.5% (SD = 18.6) of the base of the SVs were treated with EBRT, compared to 66.7% (SD = 32.6) for patients with a predicted risk of SV involvement less than 15% (<i>n</i> = 175, <i>p</i> < 0.0001). Similarly, the mean percentage of proximal and total SV volumes treated with EBRT was 75.6% (SD = 24.4) and 68.7% (SD = 26.0) for patients with a predicted risk of SV involvement of greater than 15%, compared to 50.3% (SD = 31.0, <i>p</i> < 0.0001) and 41.0% (SD = 27.8, <i>p</i> < 0.0001) for patients with a risk of less than 15%. The results indicate that all parts of the SVs are more likely to be contoured in men with >15% risk of SV involvement than those with <15% risk. However, radiation oncologists still contour a high percentage of SVs in men with <15% risk of SV involvement, suggesting that there may be over-treatment of SVs that increases the risk of rectal or bladder toxicity. |
| first_indexed | 2024-03-11T01:09:30Z |
| format | Article |
| id | doaj.art-2921f959e3f048a9b4bce6ea450afb7e |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T01:09:30Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-2921f959e3f048a9b4bce6ea450afb7e2023-11-18T18:55:53ZengMDPI AGCurrent Oncology1198-00521718-77292023-07-013076587659510.3390/curroncol30070483Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam RadiotherapyTanner Steed0Nikki Chopra1Jihyun Yun2Jordan Hill3Benjamin Burke4Sunita Ghosh5Brad Warkentin6Nawaid Usmani7Department of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, CanadaThis study retrospectively reviewed data from men with localized prostate cancer treated with external beam radiotherapy (EBRT). We identified 359 men with localized prostate cancer treated with curative EBRT at the Cross Cancer Institute between 2010–2011. The volume of seminal vesicles (SVs) treated as well as dose values were extracted. These volumes were compared to gold standard contours drawn by a trained expert based on consensus European Society for Radiotherapy and Oncology (ESTRO) contouring guidelines. Patient and tumor characteristics were extracted for these patients. Memorial Sloan Kettering prostate cancer nomogram was used to assign a predicted risk of SV involvement for each patient based on baseline tumor characteristics. In patients with a predicted risk of SV involvement greater than 15% (<i>n</i> = 184), 86.5% (SD = 18.6) of the base of the SVs were treated with EBRT, compared to 66.7% (SD = 32.6) for patients with a predicted risk of SV involvement less than 15% (<i>n</i> = 175, <i>p</i> < 0.0001). Similarly, the mean percentage of proximal and total SV volumes treated with EBRT was 75.6% (SD = 24.4) and 68.7% (SD = 26.0) for patients with a predicted risk of SV involvement of greater than 15%, compared to 50.3% (SD = 31.0, <i>p</i> < 0.0001) and 41.0% (SD = 27.8, <i>p</i> < 0.0001) for patients with a risk of less than 15%. The results indicate that all parts of the SVs are more likely to be contoured in men with >15% risk of SV involvement than those with <15% risk. However, radiation oncologists still contour a high percentage of SVs in men with <15% risk of SV involvement, suggesting that there may be over-treatment of SVs that increases the risk of rectal or bladder toxicity.https://www.mdpi.com/1718-7729/30/7/483prostateradiotherapyseminal vesiclecontour |
| spellingShingle | Tanner Steed Nikki Chopra Jihyun Yun Jordan Hill Benjamin Burke Sunita Ghosh Brad Warkentin Nawaid Usmani Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy Current Oncology prostate radiotherapy seminal vesicle contour |
| title | Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy |
| title_full | Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy |
| title_fullStr | Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy |
| title_full_unstemmed | Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy |
| title_short | Seminal Vesicle Treatment for Localized Prostate Cancer Treated with External Beam Radiotherapy |
| title_sort | seminal vesicle treatment for localized prostate cancer treated with external beam radiotherapy |
| topic | prostate radiotherapy seminal vesicle contour |
| url | https://www.mdpi.com/1718-7729/30/7/483 |
| work_keys_str_mv | AT tannersteed seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT nikkichopra seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT jihyunyun seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT jordanhill seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT benjaminburke seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT sunitaghosh seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT bradwarkentin seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy AT nawaidusmani seminalvesicletreatmentforlocalizedprostatecancertreatedwithexternalbeamradiotherapy |