The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand.
<h4>Background</h4>The human papillomavirus (HPV) vaccine was introduced into Thailand's national immunization program in 2017 for 11-12 year old school girls. The objectives of this study were to examine the epidemiological consequences and cost-effectiveness of a routine quadrival...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0245894 |
| _version_ | 1819014104357011456 |
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| author | Wichai Termrungruanglert Nipon Khemapech Apichai Vasuratna Piyalamporn Havanond Preyanuch Deebukkham Amit Sharad Kulkarni Andrew Pavelyev |
| author_facet | Wichai Termrungruanglert Nipon Khemapech Apichai Vasuratna Piyalamporn Havanond Preyanuch Deebukkham Amit Sharad Kulkarni Andrew Pavelyev |
| author_sort | Wichai Termrungruanglert |
| collection | DOAJ |
| description | <h4>Background</h4>The human papillomavirus (HPV) vaccine was introduced into Thailand's national immunization program in 2017 for 11-12 year old school girls. The objectives of this study were to examine the epidemiological consequences and cost-effectiveness of a routine quadrivalent HPV (4vHPV) vaccination and the routine 4vHPV vaccination plus 5-year catch-up vaccination by comparing with cervical cancer screening only (no vaccination) in Thailand.<h4>Method</h4>A transmission dynamic model was used to assess the cost-effectiveness of the routine 4vHPV vaccination and the routine 4vHPV vaccination plus catch-up vaccination, compared with no vaccination (screening only) in Thai population. The vaccination coverage rate assumptions were 95% in 11-12-year-old girls for the routine vaccination and 70% in 13-24 year-old females for the 5-year catch-up vaccination. Vaccination costs, direct medical costs of HPV-related diseases, and the number of quality of life years (QALYs) gained were calculated for over a 100-year time horizon with discount rate of 3%.<h4>Result</h4>The model indicated that the routine 4vHPV vaccination and the routine plus catch-up 4vHPV vaccination strategies could prevent approximately 434,130 and 472,502 cumulative cases of cervical cancer, 182,234 and 199,068 cumulative deaths from cervical cancer and 12,708,349 and 13,641,398 cumulative cases of HPV 6/11 related genital warts, respectively, when compared with no vaccination over 100 years. The estimated cost per QALY gained (ICER) when compared to no vaccination in Thailand was 8,370 THB/QALY for the routine vaccination and 9,650 THB/QALY for the routine with catch-up vaccination strategy.<h4>Conclusion</h4>Considering the recommended threshold of 160,000 THB/QALY for Thailand, the implementation of the routine 4vHPV vaccination either alone or plus the catch-up vaccination was cost-effective as compared to the cervical cancer screening only. |
| first_indexed | 2024-12-21T02:10:32Z |
| format | Article |
| id | doaj.art-2922a09321344c6caa8a8abce0845d96 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:10:32Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2922a09321344c6caa8a8abce0845d962022-12-21T19:19:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024589410.1371/journal.pone.0245894The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand.Wichai TermrungruanglertNipon KhemapechApichai VasuratnaPiyalamporn HavanondPreyanuch DeebukkhamAmit Sharad KulkarniAndrew Pavelyev<h4>Background</h4>The human papillomavirus (HPV) vaccine was introduced into Thailand's national immunization program in 2017 for 11-12 year old school girls. The objectives of this study were to examine the epidemiological consequences and cost-effectiveness of a routine quadrivalent HPV (4vHPV) vaccination and the routine 4vHPV vaccination plus 5-year catch-up vaccination by comparing with cervical cancer screening only (no vaccination) in Thailand.<h4>Method</h4>A transmission dynamic model was used to assess the cost-effectiveness of the routine 4vHPV vaccination and the routine 4vHPV vaccination plus catch-up vaccination, compared with no vaccination (screening only) in Thai population. The vaccination coverage rate assumptions were 95% in 11-12-year-old girls for the routine vaccination and 70% in 13-24 year-old females for the 5-year catch-up vaccination. Vaccination costs, direct medical costs of HPV-related diseases, and the number of quality of life years (QALYs) gained were calculated for over a 100-year time horizon with discount rate of 3%.<h4>Result</h4>The model indicated that the routine 4vHPV vaccination and the routine plus catch-up 4vHPV vaccination strategies could prevent approximately 434,130 and 472,502 cumulative cases of cervical cancer, 182,234 and 199,068 cumulative deaths from cervical cancer and 12,708,349 and 13,641,398 cumulative cases of HPV 6/11 related genital warts, respectively, when compared with no vaccination over 100 years. The estimated cost per QALY gained (ICER) when compared to no vaccination in Thailand was 8,370 THB/QALY for the routine vaccination and 9,650 THB/QALY for the routine with catch-up vaccination strategy.<h4>Conclusion</h4>Considering the recommended threshold of 160,000 THB/QALY for Thailand, the implementation of the routine 4vHPV vaccination either alone or plus the catch-up vaccination was cost-effective as compared to the cervical cancer screening only.https://doi.org/10.1371/journal.pone.0245894 |
| spellingShingle | Wichai Termrungruanglert Nipon Khemapech Apichai Vasuratna Piyalamporn Havanond Preyanuch Deebukkham Amit Sharad Kulkarni Andrew Pavelyev The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. PLoS ONE |
| title | The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. |
| title_full | The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. |
| title_fullStr | The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. |
| title_full_unstemmed | The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. |
| title_short | The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand. |
| title_sort | epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in thailand |
| url | https://doi.org/10.1371/journal.pone.0245894 |
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