Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers
Abstract Curcumin, a vital bioactive compound found naturally, has diverse biological applications. However, a major limitation of curcumin is its low bioavailability caused by its limited solubility in water. Hence, it is possible to overcome this problem through preparing oil in water nanodispersi...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Chemistry |
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| Online Access: | https://doi.org/10.1186/s13065-024-01160-z |
| _version_ | 1827301375780847616 |
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| author | Zahra Sayyar Hoda Jafarizadeh-Malmiri |
| author_facet | Zahra Sayyar Hoda Jafarizadeh-Malmiri |
| author_sort | Zahra Sayyar |
| collection | DOAJ |
| description | Abstract Curcumin, a vital bioactive compound found naturally, has diverse biological applications. However, a major limitation of curcumin is its low bioavailability caused by its limited solubility in water. Hence, it is possible to overcome this problem through preparing oil in water nanodispersion of curcumin that emulsifier can play key role to produce nanodispersion. In the present study, the effect of three emulsifiers of Tween 80, Arabic Gum and Polyethylene glycol on preparing nanodispersions with desirable properties was investigated using subcritical water method and a mixture design. Zeta-potential and particle size of the achieved nanodispersions were taken into account as outcome factors. The optimum values for emulsifiers of Tween 80, Arabic Gum and Polyethylene glycol were obtained as 0.588 g, 0.639 g and 0.273 g, respectively, using the suggested model, so that obtained nanodispersion had minimum particle size (101.89 nm) and maximum zeta-potential (−24.99 mV). In fact, 102.5 nm and − 24.7 mV were obtained from experimental data at these values of emulsifiers. In addition, maximum loading potential (0.199 g/L), efficiency (99.5%), and minimum total curcumin loss (0.5%) were acquired at these optimum values. The results also show that the nanodispersion had a powerful antioxidant activity (65.27%) with extra antibacterial activity in facing with both E. coli and S. aureus strains. Moreover, curcumin nanodispersion was significantly taken up by HT-29 cells and resulted in the production of oxidative stress in the cells, leading to a decrease in the growth of cancer cells. |
| first_indexed | 2024-04-24T16:22:06Z |
| format | Article |
| id | doaj.art-2923fc1cc73a4d94822c17252c3b8349 |
| institution | Directory Open Access Journal |
| issn | 2661-801X |
| language | English |
| last_indexed | 2024-04-24T16:22:06Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj.art-2923fc1cc73a4d94822c17252c3b83492024-03-31T11:09:50ZengBMCBMC Chemistry2661-801X2024-03-0118111110.1186/s13065-024-01160-zEnhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiersZahra Sayyar0Hoda Jafarizadeh-Malmiri1Department of Chemical Engineering, University of BonabFaculty of Chemical Engineering, Sahand University of TechnologyAbstract Curcumin, a vital bioactive compound found naturally, has diverse biological applications. However, a major limitation of curcumin is its low bioavailability caused by its limited solubility in water. Hence, it is possible to overcome this problem through preparing oil in water nanodispersion of curcumin that emulsifier can play key role to produce nanodispersion. In the present study, the effect of three emulsifiers of Tween 80, Arabic Gum and Polyethylene glycol on preparing nanodispersions with desirable properties was investigated using subcritical water method and a mixture design. Zeta-potential and particle size of the achieved nanodispersions were taken into account as outcome factors. The optimum values for emulsifiers of Tween 80, Arabic Gum and Polyethylene glycol were obtained as 0.588 g, 0.639 g and 0.273 g, respectively, using the suggested model, so that obtained nanodispersion had minimum particle size (101.89 nm) and maximum zeta-potential (−24.99 mV). In fact, 102.5 nm and − 24.7 mV were obtained from experimental data at these values of emulsifiers. In addition, maximum loading potential (0.199 g/L), efficiency (99.5%), and minimum total curcumin loss (0.5%) were acquired at these optimum values. The results also show that the nanodispersion had a powerful antioxidant activity (65.27%) with extra antibacterial activity in facing with both E. coli and S. aureus strains. Moreover, curcumin nanodispersion was significantly taken up by HT-29 cells and resulted in the production of oxidative stress in the cells, leading to a decrease in the growth of cancer cells.https://doi.org/10.1186/s13065-024-01160-zCurcumin nanodispersionSubcritical waterMixture designMixture of emulsifiersOptimizationArabic gum |
| spellingShingle | Zahra Sayyar Hoda Jafarizadeh-Malmiri Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers BMC Chemistry Curcumin nanodispersion Subcritical water Mixture design Mixture of emulsifiers Optimization Arabic gum |
| title | Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers |
| title_full | Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers |
| title_fullStr | Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers |
| title_full_unstemmed | Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers |
| title_short | Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers |
| title_sort | enhancing the efficacy of nano curcumin on cancer cells through mixture design optimization of three emulsifiers |
| topic | Curcumin nanodispersion Subcritical water Mixture design Mixture of emulsifiers Optimization Arabic gum |
| url | https://doi.org/10.1186/s13065-024-01160-z |
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