Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle
Belgian Blue cattle are known for their high degree of muscling and good carcass qualities. This high degree of muscling is mainly caused by a mutation in the myostatin gene (MSTN). Although the MSTN mutation is considered as fixed in the Belgian Blue breed, segregation is occurring in a sub-populat...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731122000076 |
| _version_ | 1818353460584644608 |
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| author | R. Meyermans S. Janssens A. Coussé W. Gorssen X. Hubin P. Mayeres W. Veulemans E. Claerebout C. Charlier N. Buys |
| author_facet | R. Meyermans S. Janssens A. Coussé W. Gorssen X. Hubin P. Mayeres W. Veulemans E. Claerebout C. Charlier N. Buys |
| author_sort | R. Meyermans |
| collection | DOAJ |
| description | Belgian Blue cattle are known for their high degree of muscling and good carcass qualities. This high degree of muscling is mainly caused by a mutation in the myostatin gene (MSTN). Although the MSTN mutation is considered as fixed in the Belgian Blue breed, segregation is occurring in a sub-population bred for dual purpose. In the latter population, we observed an association between the mutation in MSTN and susceptibility to psoroptic mange, a skin disease caused by Psoroptes ovis mites that heavily plagues Belgian Blue cattle. In total, 291 animals were sampled and screened for their susceptibility for mange lesions and their MSTN genotype. Via linear mixed modelling, we observed that homozygous mutant animals had a significant increase in the size of mange lesions (+2.51% lesion extent) compared to homozygous wild type. These findings were confirmed with zero-inflated modelling, an animal model and odds analysis. Risk ratios for developing severe mange lesions were 5.9 times as high for homozygous mutant animals. All analyses confirmed an association between the MSTN genotype and psoroptic mange lesion size. |
| first_indexed | 2024-12-13T19:09:53Z |
| format | Article |
| id | doaj.art-2924c0e893034abfa1128de774cb158b |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-13T19:09:53Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-2924c0e893034abfa1128de774cb158b2022-12-21T23:34:25ZengElsevierAnimal1751-73112022-03-01163100460Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattleR. Meyermans0S. Janssens1A. Coussé2W. Gorssen3X. Hubin4P. Mayeres5W. Veulemans6E. Claerebout7C. Charlier8N. Buys9Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, BelgiumCenter for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, BelgiumCenter for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, BelgiumCenter for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, BelgiumElevéo asbl, 5590 Ciney, BelgiumElevéo asbl, 5590 Ciney, BelgiumCRV, 6843 NW Arnhem, the NetherlandsLaboratory of Parasitology, Department Virology, Parasitology and Immunology, UGent, 9820 Merelbeke, BelgiumUnit of Animal Genomics, GIGA Institute and Faculty of Veterinary Medicine, Liège University, 4000 Liège, BelgiumCenter for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium; Corresponding author.Belgian Blue cattle are known for their high degree of muscling and good carcass qualities. This high degree of muscling is mainly caused by a mutation in the myostatin gene (MSTN). Although the MSTN mutation is considered as fixed in the Belgian Blue breed, segregation is occurring in a sub-population bred for dual purpose. In the latter population, we observed an association between the mutation in MSTN and susceptibility to psoroptic mange, a skin disease caused by Psoroptes ovis mites that heavily plagues Belgian Blue cattle. In total, 291 animals were sampled and screened for their susceptibility for mange lesions and their MSTN genotype. Via linear mixed modelling, we observed that homozygous mutant animals had a significant increase in the size of mange lesions (+2.51% lesion extent) compared to homozygous wild type. These findings were confirmed with zero-inflated modelling, an animal model and odds analysis. Risk ratios for developing severe mange lesions were 5.9 times as high for homozygous mutant animals. All analyses confirmed an association between the MSTN genotype and psoroptic mange lesion size.http://www.sciencedirect.com/science/article/pii/S1751731122000076Ectoparasitic susceptibilityGDF8MitesPsoroptes ovisScabies |
| spellingShingle | R. Meyermans S. Janssens A. Coussé W. Gorssen X. Hubin P. Mayeres W. Veulemans E. Claerebout C. Charlier N. Buys Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle Animal Ectoparasitic susceptibility GDF8 Mites Psoroptes ovis Scabies |
| title | Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle |
| title_full | Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle |
| title_fullStr | Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle |
| title_full_unstemmed | Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle |
| title_short | Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle |
| title_sort | myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose belgian blue cattle |
| topic | Ectoparasitic susceptibility GDF8 Mites Psoroptes ovis Scabies |
| url | http://www.sciencedirect.com/science/article/pii/S1751731122000076 |
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