The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema
Introduction: Air leak is one of the post-surgical complications following thoracic surgeries. Studies have shown that patients with more intraoperative air leaks are at higher risk of developing prolonged postoperative air leak. Various adjuncts have been used in attempts to reduce alveolar air lea...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-03-01
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| Series: | Journal of Cardio-Thoracic Medicine |
| Subjects: | |
| Online Access: | https://jctm.mums.ac.ir/article_19310_cee1952b728cbae9d82536c32db8919a.pdf |
| _version_ | 1818669596786294784 |
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| author | Reza Bagheri Mahsa Houra Maryam Saberi-Karimian Negin Seyfzadeh Alireza Ghodsi Hafez Teimorian Matin Moallem Shahir Davood Attaran Negar Morovatdar Seyed Ziaollah Haghi |
| author_facet | Reza Bagheri Mahsa Houra Maryam Saberi-Karimian Negin Seyfzadeh Alireza Ghodsi Hafez Teimorian Matin Moallem Shahir Davood Attaran Negar Morovatdar Seyed Ziaollah Haghi |
| author_sort | Reza Bagheri |
| collection | DOAJ |
| description | Introduction: Air leak is one of the post-surgical complications following thoracic surgeries. Studies have shown that patients with more intraoperative air leaks are at higher risk of developing prolonged postoperative air leak. Various adjuncts have been used in attempts to reduce alveolar air leaks (AAL). One of these, is the topical application of Glubran-2. This study examines the role of Glubran-2 in management of air leak in patients with chronic empyema.Methods: This was a randomized clinical trial that included 44 patients with chronic pulmonary empyema who underwent decortication and pleurectomy. They were divided into 2 equal groups. In the first group, Glubran-2 was used for management of air leak and in another group other routine methods were used for this purpose. Patients in each group were assessed according to their age, sex, location of the lesion, cause of the lesion, air leak and duration of hospitalization. The data were analyzed using the software Statistical Package for the Social Sciences (SPSS Inc, Chicago, IL) software.Results: All data of the clinical features showed no significant difference among case and control group in patients with chronic empyema at baseline (P>0.05). Alveolar air leak duration and duration of hospitalization were significantly lower in the sealant group compared to the no-sealant group (P< 0.001 and P< 0.01, respectively). Prolonged AAL (PALL) was found in 5 (50.0 %) patients in the case group and 15 (83.3 %) patients in the control group for a total of 20 (50 %) patients. There was no significant difference between the two groups regarding PAAL (P= 0.77).Conclusion: Our results support the use of Glubran-2 glue for decreasing alveolar air leak and then decreasing duration of hospitalization in the patients who underwent the thoracic surgeries. |
| first_indexed | 2024-12-17T06:54:44Z |
| format | Article |
| id | doaj.art-292cf33211f8440f810b44f8984932e8 |
| institution | Directory Open Access Journal |
| issn | 2345-2447 2322-5750 |
| language | English |
| last_indexed | 2024-12-17T06:54:44Z |
| publishDate | 2022-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardio-Thoracic Medicine |
| spelling | doaj.art-292cf33211f8440f810b44f8984932e82022-12-21T21:59:27ZengMashhad University of Medical SciencesJournal of Cardio-Thoracic Medicine2345-24472322-57502022-03-0110192593010.22038/jctm.2021.61818.135819310The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic EmpyemaReza Bagheri0Mahsa Houra1Maryam Saberi-Karimian2Negin Seyfzadeh3Alireza Ghodsi4Hafez Teimorian5Matin Moallem Shahir6Davood Attaran7Negar Morovatdar8Seyed Ziaollah Haghi9Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, IranLung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, IranStudent of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Thoracic Surgery, Thoracic Surgery Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pulmonary Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Thoracic Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranIntroduction: Air leak is one of the post-surgical complications following thoracic surgeries. Studies have shown that patients with more intraoperative air leaks are at higher risk of developing prolonged postoperative air leak. Various adjuncts have been used in attempts to reduce alveolar air leaks (AAL). One of these, is the topical application of Glubran-2. This study examines the role of Glubran-2 in management of air leak in patients with chronic empyema.Methods: This was a randomized clinical trial that included 44 patients with chronic pulmonary empyema who underwent decortication and pleurectomy. They were divided into 2 equal groups. In the first group, Glubran-2 was used for management of air leak and in another group other routine methods were used for this purpose. Patients in each group were assessed according to their age, sex, location of the lesion, cause of the lesion, air leak and duration of hospitalization. The data were analyzed using the software Statistical Package for the Social Sciences (SPSS Inc, Chicago, IL) software.Results: All data of the clinical features showed no significant difference among case and control group in patients with chronic empyema at baseline (P>0.05). Alveolar air leak duration and duration of hospitalization were significantly lower in the sealant group compared to the no-sealant group (P< 0.001 and P< 0.01, respectively). Prolonged AAL (PALL) was found in 5 (50.0 %) patients in the case group and 15 (83.3 %) patients in the control group for a total of 20 (50 %) patients. There was no significant difference between the two groups regarding PAAL (P= 0.77).Conclusion: Our results support the use of Glubran-2 glue for decreasing alveolar air leak and then decreasing duration of hospitalization in the patients who underwent the thoracic surgeries.https://jctm.mums.ac.ir/article_19310_cee1952b728cbae9d82536c32db8919a.pdfair leakcomplicationsglubran gluesurgery |
| spellingShingle | Reza Bagheri Mahsa Houra Maryam Saberi-Karimian Negin Seyfzadeh Alireza Ghodsi Hafez Teimorian Matin Moallem Shahir Davood Attaran Negar Morovatdar Seyed Ziaollah Haghi The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema Journal of Cardio-Thoracic Medicine air leak complications glubran glue surgery |
| title | The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema |
| title_full | The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema |
| title_fullStr | The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema |
| title_full_unstemmed | The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema |
| title_short | The Effects of Glubran Glue on Alveolar Air Leak in Patients with Chronic Empyema |
| title_sort | effects of glubran glue on alveolar air leak in patients with chronic empyema |
| topic | air leak complications glubran glue surgery |
| url | https://jctm.mums.ac.ir/article_19310_cee1952b728cbae9d82536c32db8919a.pdf |
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