Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke
Objective: Measurement of plasma levels of protein-conjugated acrolein (PC-Acro) together with IL-6 and CRP can be used to identify silent brain infarction (SBI) with high sensitivity and specificity. The aim of this study was to determine how these biomarkers vary during stroke. Methods: Levels of...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | eNeurologicalSci |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650217300084 |
| _version_ | 1818298434002616320 |
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| author | Madoka Yoshida Naoki Kato Takeshi Uemura Mutsumi Mizoi Mizuho Nakamura Ryotaro Saiki Keisuke Hatano Kunitomo Sato Shota Kakizaki Aya Nakamura Takuya Ishii Tohru Terao Yuichi Murayama Keiko Kashiwagi Kazuei Igarashi |
| author_facet | Madoka Yoshida Naoki Kato Takeshi Uemura Mutsumi Mizoi Mizuho Nakamura Ryotaro Saiki Keisuke Hatano Kunitomo Sato Shota Kakizaki Aya Nakamura Takuya Ishii Tohru Terao Yuichi Murayama Keiko Kashiwagi Kazuei Igarashi |
| author_sort | Madoka Yoshida |
| collection | DOAJ |
| description | Objective: Measurement of plasma levels of protein-conjugated acrolein (PC-Acro) together with IL-6 and CRP can be used to identify silent brain infarction (SBI) with high sensitivity and specificity. The aim of this study was to determine how these biomarkers vary during stroke.
Methods: Levels of PC-Acro, IL-6 and CRP in plasma were measured on day 0, 2, 7 and 14 after the onset of ischemic or hemorrhagic stroke.
Results: After the onset of stroke, the level of PC-Acro in plasma was elevated corresponding to the size of stroke. It returned to near control levels by day 2, and remained similar through day 14. The degree of the decrease in PC-Acro on day 2 was greater when the size of brain infarction or hemorrhage was larger. An increase in IL-6 and CRP occurred after the increase in PC-Acro, and it was well correlated with the size of the injury following infarction or hemorrhage. The results suggest that acrolein becomes a trigger for the production of IL-6 and CRP, as previously observed in a mouse model of stroke and in cell culture systems. The increase in IL-6 and CRP was also correlated with poor outcome judging from mRS.
Conclusion: The results indicate that the degree of the decrease in PC-Acro and the increase in IL-6 and CRP from day 0 to day 2 was correlated with the size of brain infarction, and the increase in IL-6 and CRP with poor outcome at discharge. |
| first_indexed | 2024-12-13T04:35:16Z |
| format | Article |
| id | doaj.art-292dc0a7216e457ca0fef92d395c77f2 |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-13T04:35:16Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-292dc0a7216e457ca0fef92d395c77f22022-12-21T23:59:26ZengElseviereNeurologicalSci2405-65022017-06-017C182410.1016/j.ensci.2017.03.005Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during strokeMadoka Yoshida0Naoki Kato1Takeshi Uemura2Mutsumi Mizoi3Mizuho Nakamura4Ryotaro Saiki5Keisuke Hatano6Kunitomo Sato7Shota Kakizaki8Aya Nakamura9Takuya Ishii10Tohru Terao11Yuichi Murayama12Keiko Kashiwagi13Kazuei Igarashi14Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, Atsugi Municipal Hospital, Atsugi, Kanagawa, JapanDepartment of Neurosurgery, The Jikei University School of Medicine, Minato-ku, Tokyo, JapanFaculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, JapanAmine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba, Chiba, JapanObjective: Measurement of plasma levels of protein-conjugated acrolein (PC-Acro) together with IL-6 and CRP can be used to identify silent brain infarction (SBI) with high sensitivity and specificity. The aim of this study was to determine how these biomarkers vary during stroke. Methods: Levels of PC-Acro, IL-6 and CRP in plasma were measured on day 0, 2, 7 and 14 after the onset of ischemic or hemorrhagic stroke. Results: After the onset of stroke, the level of PC-Acro in plasma was elevated corresponding to the size of stroke. It returned to near control levels by day 2, and remained similar through day 14. The degree of the decrease in PC-Acro on day 2 was greater when the size of brain infarction or hemorrhage was larger. An increase in IL-6 and CRP occurred after the increase in PC-Acro, and it was well correlated with the size of the injury following infarction or hemorrhage. The results suggest that acrolein becomes a trigger for the production of IL-6 and CRP, as previously observed in a mouse model of stroke and in cell culture systems. The increase in IL-6 and CRP was also correlated with poor outcome judging from mRS. Conclusion: The results indicate that the degree of the decrease in PC-Acro and the increase in IL-6 and CRP from day 0 to day 2 was correlated with the size of brain infarction, and the increase in IL-6 and CRP with poor outcome at discharge.http://www.sciencedirect.com/science/article/pii/S2405650217300084Brain infarctionBrain hemorrhageBiomarkersProtein-conjugated acrolein (PC-Acro)Interleukin-6C-reactive protein |
| spellingShingle | Madoka Yoshida Naoki Kato Takeshi Uemura Mutsumi Mizoi Mizuho Nakamura Ryotaro Saiki Keisuke Hatano Kunitomo Sato Shota Kakizaki Aya Nakamura Takuya Ishii Tohru Terao Yuichi Murayama Keiko Kashiwagi Kazuei Igarashi Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke eNeurologicalSci Brain infarction Brain hemorrhage Biomarkers Protein-conjugated acrolein (PC-Acro) Interleukin-6 C-reactive protein |
| title | Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke |
| title_full | Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke |
| title_fullStr | Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke |
| title_full_unstemmed | Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke |
| title_short | Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke |
| title_sort | time dependent transition of the levels of protein conjugated acrolein pc acro il 6 and crp in plasma during stroke |
| topic | Brain infarction Brain hemorrhage Biomarkers Protein-conjugated acrolein (PC-Acro) Interleukin-6 C-reactive protein |
| url | http://www.sciencedirect.com/science/article/pii/S2405650217300084 |
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