Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters
Polymeric nanocapsules have gained more and more interest in the medical sciences. Their core-shell structure offers numerous advantages, especially regarding their use as drug delivery systems. This review begins by presenting the different intrinsic sources of the instability of nanocapsules. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/8/1112 |
| _version_ | 1797522413104136192 |
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| author | Ghania Degobert Dunya Aydin |
| author_facet | Ghania Degobert Dunya Aydin |
| author_sort | Ghania Degobert |
| collection | DOAJ |
| description | Polymeric nanocapsules have gained more and more interest in the medical sciences. Their core-shell structure offers numerous advantages, especially regarding their use as drug delivery systems. This review begins by presenting the different intrinsic sources of the instability of nanocapsules. The physical and chemical potential instabilities of nanocapsules reduce their shelf-life and constitute a barrier to their clinical use and to their commercialization. To overcome these issues, lyophilization is often used as a process of choice in the pharmaceutical industry especially when labile compounds are used. The state of the art of lyophilization nanocapsules is reviewed. The formulation properties and the process parameters are discussed for a complete understanding of their impact on the stability and storage of the final dried product. To assess the quality of the dried product, various characterization methods are also discussed. |
| first_indexed | 2024-03-10T08:29:01Z |
| format | Article |
| id | doaj.art-292eb0eb62e34b7992b8b83c575e029a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:29:01Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-292eb0eb62e34b7992b8b83c575e029a2023-11-22T09:12:37ZengMDPI AGPharmaceutics1999-49232021-07-01138111210.3390/pharmaceutics13081112Lyophilization of Nanocapsules: Instability Sources, Formulation and Process ParametersGhania Degobert0Dunya Aydin1LAGEPP UMR 5007 CNRS, University of Lyon, Université Claude Bernard Lyon 1, 69622 Villeurbanne, FranceLAGEPP UMR 5007 CNRS, University of Lyon, Université Claude Bernard Lyon 1, 69622 Villeurbanne, FrancePolymeric nanocapsules have gained more and more interest in the medical sciences. Their core-shell structure offers numerous advantages, especially regarding their use as drug delivery systems. This review begins by presenting the different intrinsic sources of the instability of nanocapsules. The physical and chemical potential instabilities of nanocapsules reduce their shelf-life and constitute a barrier to their clinical use and to their commercialization. To overcome these issues, lyophilization is often used as a process of choice in the pharmaceutical industry especially when labile compounds are used. The state of the art of lyophilization nanocapsules is reviewed. The formulation properties and the process parameters are discussed for a complete understanding of their impact on the stability and storage of the final dried product. To assess the quality of the dried product, various characterization methods are also discussed.https://www.mdpi.com/1999-4923/13/8/1112nanocapsulesfreeze dryingunfreezable waterannealingprotectantstability |
| spellingShingle | Ghania Degobert Dunya Aydin Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters Pharmaceutics nanocapsules freeze drying unfreezable water annealing protectant stability |
| title | Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters |
| title_full | Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters |
| title_fullStr | Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters |
| title_full_unstemmed | Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters |
| title_short | Lyophilization of Nanocapsules: Instability Sources, Formulation and Process Parameters |
| title_sort | lyophilization of nanocapsules instability sources formulation and process parameters |
| topic | nanocapsules freeze drying unfreezable water annealing protectant stability |
| url | https://www.mdpi.com/1999-4923/13/8/1112 |
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