Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies

Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies

Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor active-form stability. To address these shortcomings, our research focuses on the encapsulation of this drug in the poly(amidoamine) (PAMAM) dend...

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Bibliographic Details
Main Authors: Ewa Oledzka, Klaudia Paśnik, Izabela Domańska, Monika Zielińska-Pisklak, Urszula Piotrowska, Marcin Sobczak, Łukasz Szeleszczuk, Anna Laskowska
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
PAMAM dendrimer
camptothecin
encapsulation
anti-cancer drug delivery systems
controlled release
drug carrier
Online Access:https://www.mdpi.com/1420-3049/28/6/2696

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