P2Y1 Receptor as a Catalyst of Brain Neurodegeneration
Different brain disorders display distinctive etiologies and pathogenic mechanisms. However, they also share pathogenic events. One event systematically occurring in different brain disorders, both acute and chronic, is the increase of the extracellular ATP levels. Accordingly, several P2 (ATP/ADP)...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | NeuroSci |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4087/3/4/43 |
| _version_ | 1797455914005954560 |
|---|---|
| author | Ricardo J. Rodrigues Ana S. Figueira Joana M. Marques |
| author_facet | Ricardo J. Rodrigues Ana S. Figueira Joana M. Marques |
| author_sort | Ricardo J. Rodrigues |
| collection | DOAJ |
| description | Different brain disorders display distinctive etiologies and pathogenic mechanisms. However, they also share pathogenic events. One event systematically occurring in different brain disorders, both acute and chronic, is the increase of the extracellular ATP levels. Accordingly, several P2 (ATP/ADP) and P1 (adenosine) receptors, as well as the ectoenzymes involved in the extracellular catabolism of ATP, have been associated to different brain pathologies, either with a neuroprotective or neurodegenerative action. The P2Y1 receptor (P2Y1R) is one of the purinergic receptors associated to different brain diseases. It has a widespread regional, cellular, and subcellular distribution in the brain, it is capable of modulating synaptic function and neuronal activity, and it is particularly important in the control of astrocytic activity and in astrocyte–neuron communication. In diverse brain pathologies, there is growing evidence of a noxious gain-of-function of P2Y1R favoring neurodegeneration by promoting astrocyte hyperactivity, entraining Ca<sup>2+</sup>-waves, and inducing the release of glutamate by directly or indirectly recruiting microglia and/or by increasing the susceptibility of neurons to damage. Here, we review the current evidence on the involvement of P2Y1R in different acute and chronic neurodegenerative brain disorders and the underlying mechanisms. |
| first_indexed | 2024-03-09T16:01:03Z |
| format | Article |
| id | doaj.art-2930664620e14672a430b2cbcd315a28 |
| institution | Directory Open Access Journal |
| issn | 2673-4087 |
| language | English |
| last_indexed | 2024-03-09T16:01:03Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | NeuroSci |
| spelling | doaj.art-2930664620e14672a430b2cbcd315a282023-11-24T17:06:21ZengMDPI AGNeuroSci2673-40872022-10-013460461510.3390/neurosci3040043P2Y1 Receptor as a Catalyst of Brain NeurodegenerationRicardo J. Rodrigues0Ana S. Figueira1Joana M. Marques2CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalCNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalCNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalDifferent brain disorders display distinctive etiologies and pathogenic mechanisms. However, they also share pathogenic events. One event systematically occurring in different brain disorders, both acute and chronic, is the increase of the extracellular ATP levels. Accordingly, several P2 (ATP/ADP) and P1 (adenosine) receptors, as well as the ectoenzymes involved in the extracellular catabolism of ATP, have been associated to different brain pathologies, either with a neuroprotective or neurodegenerative action. The P2Y1 receptor (P2Y1R) is one of the purinergic receptors associated to different brain diseases. It has a widespread regional, cellular, and subcellular distribution in the brain, it is capable of modulating synaptic function and neuronal activity, and it is particularly important in the control of astrocytic activity and in astrocyte–neuron communication. In diverse brain pathologies, there is growing evidence of a noxious gain-of-function of P2Y1R favoring neurodegeneration by promoting astrocyte hyperactivity, entraining Ca<sup>2+</sup>-waves, and inducing the release of glutamate by directly or indirectly recruiting microglia and/or by increasing the susceptibility of neurons to damage. Here, we review the current evidence on the involvement of P2Y1R in different acute and chronic neurodegenerative brain disorders and the underlying mechanisms.https://www.mdpi.com/2673-4087/3/4/43P2Y1 receptorneurodegenerationATPADPbrain |
| spellingShingle | Ricardo J. Rodrigues Ana S. Figueira Joana M. Marques P2Y1 Receptor as a Catalyst of Brain Neurodegeneration NeuroSci P2Y1 receptor neurodegeneration ATP ADP brain |
| title | P2Y1 Receptor as a Catalyst of Brain Neurodegeneration |
| title_full | P2Y1 Receptor as a Catalyst of Brain Neurodegeneration |
| title_fullStr | P2Y1 Receptor as a Catalyst of Brain Neurodegeneration |
| title_full_unstemmed | P2Y1 Receptor as a Catalyst of Brain Neurodegeneration |
| title_short | P2Y1 Receptor as a Catalyst of Brain Neurodegeneration |
| title_sort | p2y1 receptor as a catalyst of brain neurodegeneration |
| topic | P2Y1 receptor neurodegeneration ATP ADP brain |
| url | https://www.mdpi.com/2673-4087/3/4/43 |
| work_keys_str_mv | AT ricardojrodrigues p2y1receptorasacatalystofbrainneurodegeneration AT anasfigueira p2y1receptorasacatalystofbrainneurodegeneration AT joanammarques p2y1receptorasacatalystofbrainneurodegeneration |