IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways

IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways

Keloid is an abnormal fibrotic disease after cutaneous injury characterized by exaggerated scar tissue formation, which often extends beyond the boundaries of the original wound. Although chronic inflammation is known to be associated with the excessive inflammation in keloid tissue, there are few s...

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Bibliographic Details
Main Authors: Seon-Yeong Lee, A Ram Lee, Jeong Won Choi, Chae Rim Lee, Keun-Hyung Cho, Jung Ho Lee, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
keloid
autophagic flux
IL-17
stat3
HIF-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.888719/full

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