A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents
Regional anatomical structures of the brain are intimately connected to functions corresponding to specific regions and the temporospatial pattern of genetic expression and their functions from the fetal period to old age. Therefore, quantitative brain morphometry has often been employed in neurosci...
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/17/2774 |
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| author | Tadashi Shiohama Norihide Maikusa Masahiro Kawaguchi Jun Natsume Yoshiyuki Hirano Keito Saito Jun-ichi Takanashi Jacob Levman Emi Takahashi Koji Matsumoto Hajime Yokota Shinya Hattori Keita Tsujimura Daisuke Sawada Tomoko Uchida Tomozumi Takatani Katsunori Fujii Shinji Naganawa Noriko Sato Hiromichi Hamada |
| author_facet | Tadashi Shiohama Norihide Maikusa Masahiro Kawaguchi Jun Natsume Yoshiyuki Hirano Keito Saito Jun-ichi Takanashi Jacob Levman Emi Takahashi Koji Matsumoto Hajime Yokota Shinya Hattori Keita Tsujimura Daisuke Sawada Tomoko Uchida Tomozumi Takatani Katsunori Fujii Shinji Naganawa Noriko Sato Hiromichi Hamada |
| author_sort | Tadashi Shiohama |
| collection | DOAJ |
| description | Regional anatomical structures of the brain are intimately connected to functions corresponding to specific regions and the temporospatial pattern of genetic expression and their functions from the fetal period to old age. Therefore, quantitative brain morphometry has often been employed in neuroscience investigations, while controlling for the scanner effect of the scanner is a critical issue for ensuring accuracy in brain morphometric studies of rare orphan diseases due to the lack of normal reference values available for multicenter studies. This study aimed to provide across-site normal reference values of global and regional brain volumes for each sex and age group in children and adolescents. We collected magnetic resonance imaging (MRI) examinations of 846 neurotypical participants aged 6.0–17.9 years (339 male and 507 female participants) from 5 institutions comprising healthy volunteers or neurotypical patients without neurological disorders, neuropsychological disorders, or epilepsy. Regional-based analysis using the CIVET 2.1.0. pipeline provided regional brain volumes, and the measurements were across-site combined using ComBat-GAM harmonization. The normal reference values of global and regional brain volumes and lateral indices in our study could be helpful for evaluating the characteristics of the brain morphology of each individual in a clinical setting and investigating the brain morphology of ultra-rare diseases. |
| first_indexed | 2024-03-10T23:25:30Z |
| format | Article |
| id | doaj.art-2939a0b7ceda4137a91c9ec416ce940e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T23:25:30Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2939a0b7ceda4137a91c9ec416ce940e2023-11-19T07:59:25ZengMDPI AGDiagnostics2075-44182023-08-011317277410.3390/diagnostics13172774A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and AdolescentsTadashi Shiohama0Norihide Maikusa1Masahiro Kawaguchi2Jun Natsume3Yoshiyuki Hirano4Keito Saito5Jun-ichi Takanashi6Jacob Levman7Emi Takahashi8Koji Matsumoto9Hajime Yokota10Shinya Hattori11Keita Tsujimura12Daisuke Sawada13Tomoko Uchida14Tomozumi Takatani15Katsunori Fujii16Shinji Naganawa17Noriko Sato18Hiromichi Hamada19Department of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanCenter for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Aichi, JapanDepartment of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Aichi, JapanResearch Center for Child Mental Development, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Pediatrics and Pediatric Neurology, Tokyo Women’s Medical University Yachiyo Medical Center, 477-96 Owadashinden, Yachiyo-shi 276-8524, Chiba, JapanDepartment of Pediatrics and Pediatric Neurology, Tokyo Women’s Medical University Yachiyo Medical Center, 477-96 Owadashinden, Yachiyo-shi 276-8524, Chiba, JapanDivision of Newborn Medicine, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USADivision of Newborn Medicine, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USADepartment of Radiology, Chiba University Hospital, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDiagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Radiology, Chiba University Hospital, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanGroup of Brain Function and Development, Neuroscience Institute of the Graduate School of Science, Nagoya University, Nagoya 466-8550, Aichi, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanDepartment of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Aichi, JapanDepartment of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8551, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba-shi 260-8677, Chiba, JapanRegional anatomical structures of the brain are intimately connected to functions corresponding to specific regions and the temporospatial pattern of genetic expression and their functions from the fetal period to old age. Therefore, quantitative brain morphometry has often been employed in neuroscience investigations, while controlling for the scanner effect of the scanner is a critical issue for ensuring accuracy in brain morphometric studies of rare orphan diseases due to the lack of normal reference values available for multicenter studies. This study aimed to provide across-site normal reference values of global and regional brain volumes for each sex and age group in children and adolescents. We collected magnetic resonance imaging (MRI) examinations of 846 neurotypical participants aged 6.0–17.9 years (339 male and 507 female participants) from 5 institutions comprising healthy volunteers or neurotypical patients without neurological disorders, neuropsychological disorders, or epilepsy. Regional-based analysis using the CIVET 2.1.0. pipeline provided regional brain volumes, and the measurements were across-site combined using ComBat-GAM harmonization. The normal reference values of global and regional brain volumes and lateral indices in our study could be helpful for evaluating the characteristics of the brain morphology of each individual in a clinical setting and investigating the brain morphology of ultra-rare diseases.https://www.mdpi.com/2075-4418/13/17/2774ComBat-GAMstructural brain MRIvoxel-based morphometryCIVETnormal reference values |
| spellingShingle | Tadashi Shiohama Norihide Maikusa Masahiro Kawaguchi Jun Natsume Yoshiyuki Hirano Keito Saito Jun-ichi Takanashi Jacob Levman Emi Takahashi Koji Matsumoto Hajime Yokota Shinya Hattori Keita Tsujimura Daisuke Sawada Tomoko Uchida Tomozumi Takatani Katsunori Fujii Shinji Naganawa Noriko Sato Hiromichi Hamada A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents Diagnostics ComBat-GAM structural brain MRI voxel-based morphometry CIVET normal reference values |
| title | A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents |
| title_full | A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents |
| title_fullStr | A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents |
| title_full_unstemmed | A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents |
| title_short | A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents |
| title_sort | brain morphometry study with across site harmonization using a combat generalized additive model in children and adolescents |
| topic | ComBat-GAM structural brain MRI voxel-based morphometry CIVET normal reference values |
| url | https://www.mdpi.com/2075-4418/13/17/2774 |
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