Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection
The ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mo...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/12/1393 |
| _version_ | 1797546935726374912 |
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| author | Dean M. Taylor Reagan S. Haney Shirley Luckhart |
| author_facet | Dean M. Taylor Reagan S. Haney Shirley Luckhart |
| author_sort | Dean M. Taylor |
| collection | DOAJ |
| description | The ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mosquito biology. We previously established that addition of ABA to <i>Anopheles stephensi</i> larval rearing water altered immature development and life history traits of females derived from treated larvae, while addition of ABA to an infected bloodmeal increased resistance of adult female <i>A. stephensi</i> to human malaria parasite infection. Here we sought to determine whether larval treatment with ABA could similarly impact resistance to parasite infection in females derived from treated larvae and, if so, whether resistance could be extended to another parasite species. We examined nutrient levels and gene expression to demonstrate that ABA can transstadially alter resistance to a rodent malaria parasite with hallmarks of previously observed mechanisms of resistance following provision of ABA in blood to <i>A. stephensi</i>. |
| first_indexed | 2024-03-10T14:36:40Z |
| format | Article |
| id | doaj.art-293a9999ba814ce9b7c7f8739327d85b |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T14:36:40Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Genes |
| spelling | doaj.art-293a9999ba814ce9b7c7f8739327d85b2023-11-20T22:07:57ZengMDPI AGGenes2073-44252020-11-011112139310.3390/genes11121393Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite InfectionDean M. Taylor0Reagan S. Haney1Shirley Luckhart2Department of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID 83844, USADepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID 83844, USADepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID 83844, USAThe ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mosquito biology. We previously established that addition of ABA to <i>Anopheles stephensi</i> larval rearing water altered immature development and life history traits of females derived from treated larvae, while addition of ABA to an infected bloodmeal increased resistance of adult female <i>A. stephensi</i> to human malaria parasite infection. Here we sought to determine whether larval treatment with ABA could similarly impact resistance to parasite infection in females derived from treated larvae and, if so, whether resistance could be extended to another parasite species. We examined nutrient levels and gene expression to demonstrate that ABA can transstadially alter resistance to a rodent malaria parasite with hallmarks of previously observed mechanisms of resistance following provision of ABA in blood to <i>A. stephensi</i>.https://www.mdpi.com/2073-4425/11/12/1393abscisic acidmosquitomalaria<i>Anopheles</i><i>Plasmodium</i>resistance |
| spellingShingle | Dean M. Taylor Reagan S. Haney Shirley Luckhart Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection Genes abscisic acid mosquito malaria <i>Anopheles</i> <i>Plasmodium</i> resistance |
| title | Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection |
| title_full | Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection |
| title_fullStr | Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection |
| title_full_unstemmed | Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection |
| title_short | Aquatic Exposure to Abscisic Acid Transstadially Enhances <i>Anopheles stephensi</i> Resistance to Malaria Parasite Infection |
| title_sort | aquatic exposure to abscisic acid transstadially enhances i anopheles stephensi i resistance to malaria parasite infection |
| topic | abscisic acid mosquito malaria <i>Anopheles</i> <i>Plasmodium</i> resistance |
| url | https://www.mdpi.com/2073-4425/11/12/1393 |
| work_keys_str_mv | AT deanmtaylor aquaticexposuretoabscisicacidtransstadiallyenhancesianophelesstephensiiresistancetomalariaparasiteinfection AT reaganshaney aquaticexposuretoabscisicacidtransstadiallyenhancesianophelesstephensiiresistancetomalariaparasiteinfection AT shirleyluckhart aquaticexposuretoabscisicacidtransstadiallyenhancesianophelesstephensiiresistancetomalariaparasiteinfection |