Intraperitoneal alpha therapy with 224Ra-labeled microparticles combined with chemotherapy in an ovarian cancer mouse model

Intraperitoneal alpha therapy with 224Ra-labeled microparticles combined with chemotherapy in an ovarian cancer mouse model

A novel alpha-therapy consisting of 224Ra-labeled calcium carbonate microparticles (224Ra-CaCO3-MP) has been designed to treat micrometastatic peritoneal disease via intraperitoneal (IP) administration. This preclinical study aimed to evaluate its efficacy and tolerability when given as a single tre...

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Bibliographic Details
Main Authors: Roxanne Wouters, Sara Westrøm, Yani Berckmans, Matteo Riva, Jolien Ceusters, Tina B. Bønsdorff, Ignace Vergote, An Coosemans
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Medicine
Subjects:
ovarian cancer
alpha therapy
radium-224
chemotherapy
carboplatin
paclitaxel
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.995325/full

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