Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study
Abstract Background Bleeding after thyroidectomy occurs due to violent coughing during emergence. Dexmedetomidine is helpful for the smooth emergence and suppression of cough. The purpose of the present study was to compare the effects of dexmedetomidine on postoperative bleeding after thyroidectomy...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-021-01325-6 |
| _version_ | 1818611294072209408 |
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| author | Sang Hun Kim Yoo Seok Kim Seongcheol Kim Ki Tae Jung |
| author_facet | Sang Hun Kim Yoo Seok Kim Seongcheol Kim Ki Tae Jung |
| author_sort | Sang Hun Kim |
| collection | DOAJ |
| description | Abstract Background Bleeding after thyroidectomy occurs due to violent coughing during emergence. Dexmedetomidine is helpful for the smooth emergence and suppression of cough. The purpose of the present study was to compare the effects of dexmedetomidine on postoperative bleeding after thyroidectomy. Methods Randomized, double-blind, controlled trials were conducted in female patients (ASA I–II, aged 20 to 60 years). The patients were randomly allocated into two groups. Approximately 15 min before the end of the surgery, dexmedetomidine was administered (0.6 µg/kg/h) without a loading dose in group D (n = 69), and normal saline was administered in group S (n = 70) at the same infusion rate. Hemodynamic data, coughing reflex, extubation time, Ramsay sedation scale (RSS), and recovery time were assessed during the administration of the study drugs and recovery from anesthesia. The amount of postoperative hemorrhage was measured for 3 days. Results Data from a total of 139 patients were analyzed. The incidence of severe cough was significantly lower in group D than in group S (4.3 % vs. 11.5 %, P = 0.022). The emergence agitation in the postanesthetic care unit was significantly lower in group D than in group S (P = 0.01). Postoperative bleeding was significantly lower in group D than in group S until the second postoperative day (P = 0.015). Conclusions Dexmedetomidine can be helpful in decreasing bleeding after thyroidectomy by reducing coughing and emergence agitation. Trial registration This study was registered at http://clinicaltrials.gov (registration number NCT02412150, 09/04/2015). |
| first_indexed | 2024-12-16T15:28:02Z |
| format | Article |
| id | doaj.art-293de928aa874c798a2a31afec209e6b |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-16T15:28:02Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-293de928aa874c798a2a31afec209e6b2022-12-21T22:26:27ZengBMCBMC Anesthesiology1471-22532021-04-0121111010.1186/s12871-021-01325-6Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled studySang Hun Kim0Yoo Seok Kim1Seongcheol Kim2Ki Tae Jung3Department of Anesthesiology and Pain Medicine, Chosun University HospitalDepartment of Surgery, Chosun University College of Medicine, Chosun University HospitalDepartment of Anesthesiology and Pain Medicine, Chosun University HospitalDepartment of Anesthesiology and Pain Medicine, Chosun University HospitalAbstract Background Bleeding after thyroidectomy occurs due to violent coughing during emergence. Dexmedetomidine is helpful for the smooth emergence and suppression of cough. The purpose of the present study was to compare the effects of dexmedetomidine on postoperative bleeding after thyroidectomy. Methods Randomized, double-blind, controlled trials were conducted in female patients (ASA I–II, aged 20 to 60 years). The patients were randomly allocated into two groups. Approximately 15 min before the end of the surgery, dexmedetomidine was administered (0.6 µg/kg/h) without a loading dose in group D (n = 69), and normal saline was administered in group S (n = 70) at the same infusion rate. Hemodynamic data, coughing reflex, extubation time, Ramsay sedation scale (RSS), and recovery time were assessed during the administration of the study drugs and recovery from anesthesia. The amount of postoperative hemorrhage was measured for 3 days. Results Data from a total of 139 patients were analyzed. The incidence of severe cough was significantly lower in group D than in group S (4.3 % vs. 11.5 %, P = 0.022). The emergence agitation in the postanesthetic care unit was significantly lower in group D than in group S (P = 0.01). Postoperative bleeding was significantly lower in group D than in group S until the second postoperative day (P = 0.015). Conclusions Dexmedetomidine can be helpful in decreasing bleeding after thyroidectomy by reducing coughing and emergence agitation. Trial registration This study was registered at http://clinicaltrials.gov (registration number NCT02412150, 09/04/2015).https://doi.org/10.1186/s12871-021-01325-6CoughDexmedetomidineHemorrhageRamsey sedation scaleRecoveryThyroidectomy |
| spellingShingle | Sang Hun Kim Yoo Seok Kim Seongcheol Kim Ki Tae Jung Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study BMC Anesthesiology Cough Dexmedetomidine Hemorrhage Ramsey sedation scale Recovery Thyroidectomy |
| title | Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study |
| title_full | Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study |
| title_fullStr | Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study |
| title_full_unstemmed | Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study |
| title_short | Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study |
| title_sort | dexmedetomidine decreased the post thyroidectomy bleeding by reducing cough and emergence agitation a randomized double blind controlled study |
| topic | Cough Dexmedetomidine Hemorrhage Ramsey sedation scale Recovery Thyroidectomy |
| url | https://doi.org/10.1186/s12871-021-01325-6 |
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