TMSCF2Br as both a C1 synthon and a F1 reagent
This highlight summarizes a recent development of KF-promoted three-component fluorination-aminocarbonylation reaction of aldehydes, tertiary amines, and TMSCF2Br for the synthesis of structurally important α-fluoroamide derivatives. The key to the success of this method could be attributed to the m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2022-11-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922000199 |
| Summary: | This highlight summarizes a recent development of KF-promoted three-component fluorination-aminocarbonylation reaction of aldehydes, tertiary amines, and TMSCF2Br for the synthesis of structurally important α-fluoroamide derivatives. The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor (TMSCF2Br) as both a C1 synthon and a F1 reagent through the process of C–F bond cleavage and C–F bond re-formation. |
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| ISSN: | 2666-5549 |