3D Bioprinting for Pancreas Engineering/Manufacturing
Diabetes is the most common chronic disease in the world, and it brings a heavy burden to people’s health. Against this background, diabetic research, including islet functionalization has become a hot topic in medical institutions all over the world. Especially with the rapid development of microen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/23/5143 |
| _version_ | 1797462298751664128 |
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| author | Yukun Xu Dabin Song Xiaohong Wang |
| author_facet | Yukun Xu Dabin Song Xiaohong Wang |
| author_sort | Yukun Xu |
| collection | DOAJ |
| description | Diabetes is the most common chronic disease in the world, and it brings a heavy burden to people’s health. Against this background, diabetic research, including islet functionalization has become a hot topic in medical institutions all over the world. Especially with the rapid development of microencapsulation and three-dimensional (3D) bioprinting technologies, organ engineering and manufacturing have become the main trends for disease modeling and drug screening. Especially the advanced 3D models of pancreatic islets have shown better physiological functions than monolayer cultures, suggesting their potential in elucidating the behaviors of cells under different growth environments. This review mainly summarizes the latest progress of islet capsules and 3D printed pancreatic organs and introduces the activities of islet cells in the constructs with different encapsulation technologies and polymeric materials, as well as the vascularization and blood glucose control capabilities of these constructs after implantation. The challenges and perspectives of the pancreatic organ engineering/manufacturing technologies have also been demonstrated. |
| first_indexed | 2024-03-09T17:34:34Z |
| format | Article |
| id | doaj.art-293df638339247e9b1fbb58e98ff20ae |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T17:34:34Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-293df638339247e9b1fbb58e98ff20ae2023-11-24T11:59:05ZengMDPI AGPolymers2073-43602022-11-011423514310.3390/polym142351433D Bioprinting for Pancreas Engineering/ManufacturingYukun Xu0Dabin Song1Xiaohong Wang2Center of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University, Shenyang 110122, ChinaCenter of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University, Shenyang 110122, ChinaCenter of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University, Shenyang 110122, ChinaDiabetes is the most common chronic disease in the world, and it brings a heavy burden to people’s health. Against this background, diabetic research, including islet functionalization has become a hot topic in medical institutions all over the world. Especially with the rapid development of microencapsulation and three-dimensional (3D) bioprinting technologies, organ engineering and manufacturing have become the main trends for disease modeling and drug screening. Especially the advanced 3D models of pancreatic islets have shown better physiological functions than monolayer cultures, suggesting their potential in elucidating the behaviors of cells under different growth environments. This review mainly summarizes the latest progress of islet capsules and 3D printed pancreatic organs and introduces the activities of islet cells in the constructs with different encapsulation technologies and polymeric materials, as well as the vascularization and blood glucose control capabilities of these constructs after implantation. The challenges and perspectives of the pancreatic organ engineering/manufacturing technologies have also been demonstrated.https://www.mdpi.com/2073-4360/14/23/51433D bioprintingorgan engineering/manufacturingvascularizationbioartificial pancreasstem cells |
| spellingShingle | Yukun Xu Dabin Song Xiaohong Wang 3D Bioprinting for Pancreas Engineering/Manufacturing Polymers 3D bioprinting organ engineering/manufacturing vascularization bioartificial pancreas stem cells |
| title | 3D Bioprinting for Pancreas Engineering/Manufacturing |
| title_full | 3D Bioprinting for Pancreas Engineering/Manufacturing |
| title_fullStr | 3D Bioprinting for Pancreas Engineering/Manufacturing |
| title_full_unstemmed | 3D Bioprinting for Pancreas Engineering/Manufacturing |
| title_short | 3D Bioprinting for Pancreas Engineering/Manufacturing |
| title_sort | 3d bioprinting for pancreas engineering manufacturing |
| topic | 3D bioprinting organ engineering/manufacturing vascularization bioartificial pancreas stem cells |
| url | https://www.mdpi.com/2073-4360/14/23/5143 |
| work_keys_str_mv | AT yukunxu 3dbioprintingforpancreasengineeringmanufacturing AT dabinsong 3dbioprintingforpancreasengineeringmanufacturing AT xiaohongwang 3dbioprintingforpancreasengineeringmanufacturing |