Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model

Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model

Summary: Heterogeneity of gene expression and rarity of replication hamper molecular analysis of β-cell mass restoration in adult pancreas. Here, we show transcriptional dynamics in β-cell replication process by single-cell RNA sequencing of murine pancreas with or without partial pancreatectomy. We...

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Bibliographic Details
Main Authors: Hisato Tatsuoka, Satoko Sakamoto, Daisuke Yabe, Ryotaro Kabai, Unyanee Kato, Tatsuya Okumura, Ainur Botagarova, Shinsuke Tokumoto, Ryota Usui, Masahito Ogura, Kazuaki Nagashima, Eri Mukai, Yoshio Fujitani, Akira Watanabe, Nobuya Inagaki
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309718

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